251816

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3659998..3660500 Replicon chromosome
Accession NZ_CP101292
Organism Escherichia coli strain 2003-3014

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag NMK58_RS19025 Protein ID WP_000767829.1
Coordinates 3659998..3660252 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag NMK58_RS19030 Protein ID WP_001259255.1
Coordinates 3660249..3660500 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMK58_RS18995 (3655013) 3655013..3655240 - 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -
NMK58_RS19000 (3655254) 3655254..3656312 - 1059 WP_000492324.1 thiosulfate utilization transporter TsuA/YeeE -
NMK58_RS19005 (3656491) 3656491..3657849 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
NMK58_RS19010 (3657839) 3657839..3657901 - 63 WP_010723108.1 membrane protein YoeI -
NMK58_RS19015 (3658116) 3658116..3659045 - 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
NMK58_RS19020 (3659091) 3659091..3659915 - 825 WP_000754737.1 SDR family oxidoreductase -
NMK58_RS19025 (3659998) 3659998..3660252 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
NMK58_RS19030 (3660249) 3660249..3660500 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
NMK58_RS19035 (3660783) 3660783..3660830 + 48 WP_001375657.1 his operon leader peptide -
NMK58_RS19040 (3660976) 3660976..3661875 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
NMK58_RS19045 (3661881) 3661881..3663185 + 1305 WP_000009589.1 histidinol dehydrogenase -
NMK58_RS19050 (3663182) 3663182..3664252 + 1071 WP_000108914.1 histidinol-phosphate transaminase -
NMK58_RS19055 (3664252) 3664252..3665319 + 1068 WP_000080089.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T251816 WP_000767829.1 NZ_CP101292:c3660252-3659998 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT251816 WP_001259255.1 NZ_CP101292:c3660500-3660249 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References