Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2912481..2913210 Replicon chromosome
Accession NC_015381
Organism Burkholderia gladioli BSR3

Toxin (Protein)


Gene name higB Uniprot ID F2LFJ4
Locus tag BGLA_RS12575 Protein ID WP_013698487.1
Coordinates 2912899..2913210 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID F2LFJ3
Locus tag BGLA_RS12570 Protein ID WP_013698486.1
Coordinates 2912481..2912897 (-) Length 139 a.a.

Genomic Context

BGLA_RS39990BGLA_RS12565BGLA_RS12550BGLA_RS12555BGLA_RS39995BGLA_RS12560BGLA_RS12570BGLA_RS12575BGLA_RS12580BGLA_RS12585BGLA_RS41215
Location: 2908026..2908583 (558 bp)
Type: Others
Protein ID: WP_013698480.1
Location: 2911933..2912316 (384 bp)
Type: Others
Protein ID: WP_013698485.1
Location: 2908725..2909387 (663 bp)
Type: Others
Protein ID: WP_013698481.1
Location: 2909384..2910523 (1140 bp)
Type: Others
Protein ID: WP_013698482.1
Location: 2910527..2911153 (627 bp)
Type: Others
Protein ID: WP_013698483.1
Location: 2911153..2911620 (468 bp)
Type: Others
Protein ID: WP_013698484.1
Location: 2912481..2912897 (417 bp)
Type: Antitoxin
Protein ID: WP_013698486.1
Location: 2912899..2913210 (312 bp)
Type: Toxin
Protein ID: WP_013698487.1
Location: 2913291..2914547 (1257 bp)
Type: Others
Protein ID: WP_013698488.1
Location: 2914859..2916478 (1620 bp)
Type: Others
Protein ID: WP_013698489.1
Location: 2916861..2917280 (420 bp)
Type: Others
Protein ID: Protein_2543
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BGLA_RS399902908026..2908583+558WP_013698480.1toll/interleukin-1 receptor domain-containing protein-
BGLA_RS125502908725..2909387-663WP_013698481.1uracil-DNA glycosylase-
BGLA_RS125552909384..2910523-1140WP_013698482.1nucleoside triphosphate pyrophosphohydrolase family protein-
BGLA_RS399952910527..2911153-627WP_013698483.1hypothetical protein-
BGLA_RS125602911153..2911620-468WP_013698484.1TIR domain-containing protein-
BGLA_RS125652911933..2912316+384WP_013698485.1AlpA family phage regulatory protein-
BGLA_RS125702912481..2912897-417WP_013698486.1transcriptional regulatorAntitoxin
BGLA_RS125752912899..2913210-312WP_013698487.1type II toxin-antitoxin system HigB family toxinToxin
BGLA_RS125802913291..2914547-1257WP_013698488.1site-specific integrase-
BGLA_RS125852914859..2916478-1620WP_013698489.1glutamine-hydrolyzing GMP synthase-
BGLA_RS412152916861..2917280-420Protein_2543hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIntegrative and Conjugative Element--2871875..291454742672


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(83-136)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12258.94 Da        Isoelectric Point: 9.6242

>T25181 WP_013698487.1 NC_015381:c2913210-2912899 [Burkholderia gladioli BSR3]
MHVISRKPFSDAAKAYPNDAEAIDRTYRVLRSGDFDTPQALRQVFPSLDNFKYKDKWWVLDIGGNNLRLIAFIEFRDNRM
YVKHITTHAEYDKLCKRYRKEGD

Download         Length: 312 bp

>T25181 NC_015381:c2913210-2912899 [Burkholderia gladioli BSR3]
ATGCACGTCATATCCAGAAAGCCGTTCAGCGACGCAGCAAAGGCTTATCCGAACGACGCCGAGGCGATCGACCGCACCTA
CCGGGTGCTGCGATCCGGCGATTTCGATACACCGCAAGCACTGCGACAGGTTTTTCCGTCGCTGGATAACTTCAAGTACA
AGGACAAGTGGTGGGTGCTGGACATCGGTGGCAACAATCTTCGACTGATTGCCTTCATCGAGTTTCGCGACAACCGCATG
TACGTCAAGCACATCACAACCCATGCCGAGTACGACAAGCTTTGCAAACGCTACCGGAAGGAGGGCGACTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15184.26 Da        Isoelectric Point: 4.6805

>AT25181 WP_013698486.1 NC_015381:c2912897-2912481 [Burkholderia gladioli BSR3]
MGFAAIKERAHALFDEAGFIGHIANEDDYAQALALMDELVEDYEANRPLIEILARSIEIWENESDEFAAFNARVAKLGGV
DVLRLLMEQHGLGVADLPEIGSKSLVSKILNGRGRNLTRDHIAALSKRFSVSPAVFFS

Download         Length: 417 bp

>AT25181 NC_015381:c2912897-2912481 [Burkholderia gladioli BSR3]
ATGGGATTTGCCGCCATCAAGGAACGAGCCCATGCCTTGTTCGACGAGGCGGGTTTCATTGGCCATATCGCCAATGAAGA
TGATTACGCCCAGGCGCTGGCGTTGATGGATGAACTGGTCGAAGACTACGAGGCCAACCGCCCACTGATCGAGATCCTGG
CCCGTTCCATCGAAATATGGGAAAACGAGTCCGACGAGTTTGCGGCGTTCAACGCGCGCGTGGCGAAGCTGGGCGGGGTC
GATGTGCTGCGATTGTTGATGGAGCAGCATGGACTGGGCGTGGCAGATCTGCCGGAGATCGGTAGTAAGTCACTGGTATC
CAAGATTCTCAACGGTCGGGGACGCAACTTGACCCGCGACCACATCGCAGCATTGAGCAAGCGGTTCTCAGTCAGTCCGG
CTGTTTTCTTCAGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBF2LFJ4

Antitoxin

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Source
ID
Structure
AlphaFold DBF2LFJ3

References