Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 2764669..2765040 Replicon chromosome
Accession NZ_CP101292
Organism Escherichia coli strain 2003-3014

Toxin (Protein)


Gene name ralR Uniprot ID A0A0D6ZRD3
Locus tag NMK58_RS14345 Protein ID WP_001443846.1
Coordinates 2764891..2765040 (-) Length 50 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 2764669..2764847 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMK58_RS14320 (2760624) 2760624..2761997 + 1374 WP_000123745.1 ATP-dependent RNA helicase DbpA -
NMK58_RS14325 (2762126) 2762126..2763061 - 936 WP_001157407.1 tRNA 2-thiocytidine(32) synthetase TtcA -
NMK58_RS14330 (2763113) 2763113..2764348 - 1236 WP_000040851.1 site-specific integrase -
NMK58_RS14335 (2764350) 2764350..2764565 - 216 WP_000079604.1 excisionase XisR -
- (2764669) 2764669..2764847 + 179 NuclAT_0 - Antitoxin
- (2764669) 2764669..2764847 + 179 NuclAT_0 - Antitoxin
- (2764669) 2764669..2764847 + 179 NuclAT_0 - Antitoxin
- (2764669) 2764669..2764847 + 179 NuclAT_0 - Antitoxin
NMK58_RS14340 (2764665) 2764665..2764853 - 189 WP_001302840.1 DUF1187 family protein -
NMK58_RS14345 (2764891) 2764891..2765040 - 150 WP_001443846.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
NMK58_RS14350 (2765096) 2765096..2765905 - 810 WP_000166313.1 recombination protein RecT -
NMK58_RS14355 (2765898) 2765898..2768498 - 2601 WP_000105150.1 exodeoxyribonuclease VIII -
NMK58_RS14360 (2768600) 2768600..2768875 - 276 WP_000632297.1 protein RacC -
NMK58_RS14365 (2768950) 2768950..2769120 - 171 WP_001352098.1 YdaE family protein -
NMK58_RS14370 (2769120) 2769120..2769341 - 222 WP_000560223.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - espX7/nleL 2755859..2813076 57217


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-48)


Sequences

Toxin        


Download         Length: 50 a.a.        Molecular weight: 5383.12 Da        Isoelectric Point: 8.3398

>T251804 WP_001443846.1 NZ_CP101292:c2765040-2764891 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALER

Download         Length: 150 bp

Antitoxin


Download         Length: 179 bp

>AT251804 NZ_CP101292:2764669-2764847 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6ZRD3

Antitoxin

Download structure file

References