251803

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2439203..2439998 Replicon chromosome
Accession NZ_CP101292
Organism Escherichia coli strain 2003-3014

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag NMK58_RS12460 Protein ID WP_000854914.1
Coordinates 2439624..2439998 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7U9LM11
Locus tag NMK58_RS12455 Protein ID WP_001280953.1
Coordinates 2439203..2439577 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMK58_RS12425 (2434558) 2434558..2435463 + 906 WP_000203541.1 diguanylate cyclase regulator RdcB family protein -
NMK58_RS12430 (2435460) 2435460..2436530 + 1071 WP_000102669.1 patatin-like phospholipase family protein -
NMK58_RS12435 (2436870) 2436870..2437688 + 819 WP_001234682.1 DUF932 domain-containing protein -
NMK58_RS12440 (2437779) 2437779..2438264 + 486 WP_000214398.1 antirestriction protein -
NMK58_RS12445 (2438280) 2438280..2438756 + 477 WP_001186738.1 RadC family protein -
NMK58_RS12450 (2438819) 2438819..2439040 + 222 WP_000692323.1 DUF987 domain-containing protein -
NMK58_RS12455 (2439203) 2439203..2439577 + 375 WP_001280953.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NMK58_RS12460 (2439624) 2439624..2439998 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
NMK58_RS12465 (2439995) 2439995..2440486 + 492 WP_000976857.1 DUF5983 family protein -
NMK58_RS12470 (2440498) 2440498..2440695 + 198 WP_000839282.1 DUF957 domain-containing protein -
NMK58_RS12475 (2440780) 2440780..2441622 + 843 WP_001280481.1 DUF4942 domain-containing protein -
NMK58_RS12485 (2442093) 2442093..2443031 + 939 WP_000351317.1 glyoxylate/hydroxypyruvate reductase GhrA -
NMK58_RS12490 (2443086) 2443086..2443823 + 738 WP_000283664.1 zinc-binding phosphatase -
NMK58_RS12495 (2443847) 2443847..2444401 + 555 WP_001001902.1 molecular chaperone YcdY -
NMK58_RS12500 (2444503) 2444503..2444994 + 492 WP_001297187.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgG / csgF / csgE / csgD / csgB / csgA / csgC 2438280..2450559 12279


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T251803 WP_000854914.1 NZ_CP101292:2439624-2439998 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13734.56 Da        Isoelectric Point: 6.6249

>AT251803 WP_001280953.1 NZ_CP101292:2439203-2439577 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPALATTS

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LM11

References