Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 711285..711697 Replicon chromosome
Accession NZ_CP101292
Organism Escherichia coli strain 2003-3014

Toxin (Protein)


Gene name symE Uniprot ID A0A0F3WCK2
Locus tag NMK58_RS03420 Protein ID WP_000132621.1
Coordinates 711285..711626 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 711621..711697 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMK58_RS03400 (707295) 707295..708707 - 1413 WP_024017780.1 PLP-dependent aminotransferase family protein -
NMK58_RS03405 (708884) 708884..709048 + 165 WP_000394276.1 DUF1127 domain-containing protein -
NMK58_RS03410 (709145) 709145..710027 + 883 Protein_661 DUF262 domain-containing protein -
NMK58_RS03415 (710075) 710075..711238 + 1164 WP_071531326.1 DUF1524 domain-containing protein -
NMK58_RS03420 (711285) 711285..711626 - 342 WP_000132621.1 endoribonuclease SymE Toxin
- (711621) 711621..711697 + 77 NuclAT_28 - Antitoxin
- (711621) 711621..711697 + 77 NuclAT_28 - Antitoxin
- (711621) 711621..711697 + 77 NuclAT_28 - Antitoxin
- (711621) 711621..711697 + 77 NuclAT_28 - Antitoxin
- (711621) 711621..711697 + 77 NuclAT_29 - Antitoxin
- (711621) 711621..711697 + 77 NuclAT_29 - Antitoxin
- (711621) 711621..711697 + 77 NuclAT_29 - Antitoxin
- (711621) 711621..711697 + 77 NuclAT_29 - Antitoxin
NMK58_RS03425 (711847) 711847..713616 - 1770 WP_000110079.1 restriction endonuclease subunit S -
NMK58_RS03430 (713616) 713616..715085 - 1470 WP_001341289.1 N-6 DNA methylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12342.12 Da        Isoelectric Point: 7.8218

>T251798 WP_000132621.1 NZ_CP101292:c711626-711285 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPTAEESE
LMQSLRQVCKLSARKQKQVQDFIGVITGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT251798 NZ_CP101292:711621-711697 [Escherichia coli]
AGTCATAACTGCTATTCTCCGATAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F3WCK2

Antitoxin

Download structure file

References