Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4860727..4861329 Replicon chromosome
Accession NZ_CP101274
Organism Escherichia coli strain EC21Z-014

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag NML17_RS23675 Protein ID WP_000897305.1
Coordinates 4860727..4861038 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NML17_RS23680 Protein ID WP_000356397.1
Coordinates 4861039..4861329 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML17_RS23645 (4855757) 4855757..4856542 + 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -
NML17_RS23650 (4856641) 4856641..4857240 + 600 WP_001295269.1 glucose-1-phosphatase -
NML17_RS23655 (4857234) 4857234..4858106 + 873 WP_000920762.1 virulence factor BrkB family protein -
NML17_RS23660 (4858103) 4858103..4858540 + 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
NML17_RS23665 (4858585) 4858585..4859526 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
NML17_RS23670 (4859590) 4859590..4860498 - 909 WP_001162704.1 alpha/beta hydrolase -
NML17_RS23675 (4860727) 4860727..4861038 + 312 WP_000897305.1 hypothetical protein Toxin
NML17_RS23680 (4861039) 4861039..4861329 + 291 WP_000356397.1 NadS family protein Antitoxin
NML17_RS23685 (4861934) 4861934..4862152 + 219 WP_001315930.1 CopG family transcriptional regulator -
NML17_RS23690 (4862372) 4862372..4862614 + 243 WP_001087409.1 protein YiiF -
NML17_RS23695 (4862944) 4862944..4863873 - 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
NML17_RS23700 (4863870) 4863870..4864505 - 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
NML17_RS23705 (4864502) 4864502..4865404 - 903 WP_000331377.1 formate dehydrogenase O subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T251777 WP_000897305.1 NZ_CP101274:4860727-4861038 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT251777 WP_000356397.1 NZ_CP101274:4861039-4861329 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References