251770

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2833759..2834261 Replicon chromosome
Accession NZ_CP101274
Organism Escherichia coli strain EC21Z-014

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag NML17_RS13905 Protein ID WP_000767829.1
Coordinates 2833759..2834013 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S1Y4D6
Locus tag NML17_RS13910 Protein ID WP_001259254.1
Coordinates 2834010..2834261 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML17_RS13875 (2828774) 2828774..2829001 - 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -
NML17_RS13880 (2829015) 2829015..2830073 - 1059 WP_024193414.1 thiosulfate utilization transporter TsuA/YeeE -
NML17_RS13885 (2830252) 2830252..2831610 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
NML17_RS13890 (2831600) 2831600..2831662 - 63 WP_010723108.1 membrane protein YoeI -
NML17_RS13895 (2831877) 2831877..2832806 - 930 WP_113440264.1 LysR substrate-binding domain-containing protein -
NML17_RS13900 (2832852) 2832852..2833676 - 825 WP_000754737.1 SDR family oxidoreductase -
NML17_RS13905 (2833759) 2833759..2834013 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
NML17_RS13910 (2834010) 2834010..2834261 - 252 WP_001259254.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
NML17_RS13915 (2834544) 2834544..2834594 + 51 WP_001364200.1 his operon leader peptide -
NML17_RS13920 (2834740) 2834740..2835639 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
NML17_RS13925 (2835645) 2835645..2836949 + 1305 WP_075826842.1 histidinol dehydrogenase -
NML17_RS13930 (2836946) 2836946..2838016 + 1071 WP_000108970.1 histidinol-phosphate transaminase -
NML17_RS13935 (2838016) 2838016..2839083 + 1068 WP_000080097.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T251770 WP_000767829.1 NZ_CP101274:c2834013-2833759 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9292.57 Da        Isoelectric Point: 4.5822

>AT251770 WP_001259254.1 NZ_CP101274:c2834261-2834010 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGIGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A2S1Y4D6

References