Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 2074623..2074994 Replicon chromosome
Accession NZ_CP101274
Organism Escherichia coli strain EC21Z-014

Toxin (Protein)


Gene name ralR Uniprot ID F4VC37
Locus tag NML17_RS10095 Protein ID WP_001317028.1
Coordinates 2074800..2074994 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 2074623..2074801 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML17_RS10070 (2070578) 2070578..2071951 + 1374 WP_000123745.1 ATP-dependent RNA helicase DbpA -
NML17_RS10075 (2072080) 2072080..2073015 - 936 WP_001153728.1 tRNA 2-thiocytidine(32) synthetase TtcA -
NML17_RS10080 (2073067) 2073067..2074302 - 1236 WP_000040852.1 site-specific integrase -
NML17_RS10085 (2074304) 2074304..2074519 - 216 WP_000079604.1 excisionase XisR -
- (2074623) 2074623..2074801 + 179 NuclAT_0 - Antitoxin
- (2074623) 2074623..2074801 + 179 NuclAT_0 - Antitoxin
- (2074623) 2074623..2074801 + 179 NuclAT_0 - Antitoxin
- (2074623) 2074623..2074801 + 179 NuclAT_0 - Antitoxin
NML17_RS10090 (2074598) 2074598..2074807 - 210 WP_000276809.1 double-strand break reduction protein RcbA -
NML17_RS10095 (2074800) 2074800..2074994 - 195 WP_001317028.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
NML17_RS10100 (2075051) 2075051..2075860 - 810 WP_000166319.1 recombination protein RecT -
NML17_RS10105 (2075853) 2075853..2078453 - 2601 WP_001532611.1 exodeoxyribonuclease VIII -
NML17_RS10110 (2078555) 2078555..2078830 - 276 WP_000632297.1 protein RacC -
NML17_RS10115 (2078905) 2078905..2079075 - 171 WP_001352098.1 YdaE family protein -
NML17_RS10120 (2079075) 2079075..2079296 - 222 WP_000560225.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-54)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7018.89 Da        Isoelectric Point: 8.9538

>T251761 WP_001317028.1 NZ_CP101274:c2074994-2074800 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

Antitoxin


Download         Length: 179 bp

>AT251761 NZ_CP101274:2074623-2074801 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHV7

Antitoxin

Download structure file

References