Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1798861..1799481 Replicon chromosome
Accession NC_015376
Organism Burkholderia gladioli BSR3

Toxin (Protein)


Gene name higB Uniprot ID F2LMZ4
Locus tag BGLA_RS26615 Protein ID WP_013690205.1
Coordinates 1799203..1799481 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID F2LMZ3
Locus tag BGLA_RS26610 Protein ID WP_013690204.1
Coordinates 1798861..1799184 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BGLA_RS26590 1794575..1794988 - 414 WP_013690200.1 MarR family transcriptional regulator -
BGLA_RS26595 1795096..1796274 - 1179 WP_013690201.1 HPP family protein -
BGLA_RS26600 1796669..1797625 + 957 WP_013690202.1 LysR family transcriptional regulator -
BGLA_RS26605 1797668..1798753 - 1086 WP_013690203.1 ionic transporter y4hA -
BGLA_RS26610 1798861..1799184 - 324 WP_013690204.1 HigA family addiction module antidote protein Antitoxin
BGLA_RS26615 1799203..1799481 - 279 WP_013690205.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BGLA_RS26620 1799724..1800392 + 669 WP_013690206.1 MarC family protein -
BGLA_RS26625 1800510..1801379 - 870 WP_013690207.1 CPBP family intramembrane metalloprotease -
BGLA_RS26630 1801645..1802367 - 723 WP_013690208.1 fumarylacetoacetate hydrolase family protein -
BGLA_RS26635 1802739..1803638 - 900 Protein_1491 helix-turn-helix transcriptional regulator -
BGLA_RS26640 1803831..1804433 - 603 WP_013690210.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(11-91)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10374.96 Da        Isoelectric Point: 9.2600

>T25176 WP_013690205.1 NC_015376:c1799481-1799203 [Burkholderia gladioli BSR3]
MIQSFRCKRTAALFAGESPPAWRAVAQVARRKLAMLDAAQALRDLAVPPGDPLEGLFGDRAGQYSIRINERWRLCFVWSS
RGTELVEIVDYH

Download         Length: 279 bp

>T25176 NC_015376:c1799481-1799203 [Burkholderia gladioli BSR3]
ATGATCCAGTCATTCCGATGCAAGCGCACCGCCGCGCTGTTCGCCGGCGAATCGCCGCCGGCCTGGCGTGCCGTGGCACA
AGTGGCCCGGCGCAAGCTCGCCATGCTCGATGCGGCCCAGGCGCTGCGCGACCTGGCCGTGCCGCCCGGCGACCCGCTCG
AAGGCCTGTTCGGCGATCGCGCGGGGCAATACAGCATCCGGATCAACGAGCGCTGGCGCCTCTGTTTCGTCTGGAGCAGC
CGGGGCACCGAACTCGTCGAGATCGTCGATTACCACTGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11862.67 Da        Isoelectric Point: 7.2024

>AT25176 WP_013690204.1 NC_015376:c1799184-1798861 [Burkholderia gladioli BSR3]
MNAKSVKPVNAMPAIHPGEILREEFLAPLALSVNALSLALMVPATRMHEIVNERRGITADTAYRLSRYFGTTPEFWLALQ
ADYDIKTLPNRDEIDRKVDARPTGAAA

Download         Length: 324 bp

>AT25176 NC_015376:c1799184-1798861 [Burkholderia gladioli BSR3]
ATGAATGCCAAGAGTGTGAAGCCCGTCAACGCGATGCCCGCCATCCACCCCGGCGAAATCCTGCGCGAGGAGTTCCTGGC
GCCGCTCGCGCTCAGCGTCAACGCGCTGTCGCTGGCGCTGATGGTGCCGGCCACCCGCATGCACGAGATCGTCAACGAGC
GGCGCGGCATCACCGCCGACACGGCCTACCGCCTGTCGCGCTACTTCGGCACCACGCCGGAGTTCTGGCTGGCCCTGCAG
GCCGACTACGACATCAAGACCCTGCCGAACCGCGACGAGATCGACCGCAAGGTCGATGCGCGCCCCACCGGCGCGGCGGC
CTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F2LMZ4

Antitoxin

Source ID Structure
AlphaFold DB F2LMZ3

References