251758

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 827865..828406 Replicon chromosome
Accession NZ_CP101274
Organism Escherichia coli strain EC21Z-014

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag NML17_RS03850 Protein ID WP_000615976.1
Coordinates 827865..828143 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag NML17_RS03855 Protein ID WP_000729704.1
Coordinates 828146..828406 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML17_RS03835 (825447) 825447..826025 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
NML17_RS03840 (826231) 826231..826998 + 768 WP_000333380.1 class II glutamine amidotransferase -
NML17_RS03845 (826969) 826969..827709 - 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
NML17_RS03850 (827865) 827865..828143 - 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
NML17_RS03855 (828146) 828146..828406 - 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
NML17_RS03860 (828592) 828592..829365 + 774 WP_000543895.1 C40 family peptidase -
NML17_RS03865 (829422) 829422..829778 - 357 WP_001030483.1 type II toxin-antitoxin system HicB family antitoxin -
NML17_RS03870 (829771) 829771..830049 - 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
NML17_RS03875 (830154) 830154..831866 - 1713 Protein_747 flagellar biosynthesis protein FlhA -
NML17_RS03880 (831838) 831838..832623 + 786 WP_000207575.1 putative lateral flagellar export/assembly protein LafU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - rhs/PAAR / gmhA/lpcA 812451..830049 17598


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T251758 WP_000615976.1 NZ_CP101274:c828143-827865 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT251758 WP_000729704.1 NZ_CP101274:c828406-828146 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6Z6

References