Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4602225..4602827 Replicon chromosome
Accession NZ_CP101269
Organism Escherichia coli strain EC21Z-048

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag NML18_RS22335 Protein ID WP_000897305.1
Coordinates 4602516..4602827 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NML18_RS22330 Protein ID WP_000356397.1
Coordinates 4602225..4602515 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML18_RS22305 (4598151) 4598151..4599053 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
NML18_RS22310 (4599050) 4599050..4599685 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
NML18_RS22315 (4599682) 4599682..4600611 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
NML18_RS22320 (4600941) 4600941..4601183 - 243 WP_001086388.1 protein YiiF -
NML18_RS22325 (4601402) 4601402..4601620 - 219 WP_001295676.1 CopG family transcriptional regulator -
NML18_RS22330 (4602225) 4602225..4602515 - 291 WP_000356397.1 NadS family protein Antitoxin
NML18_RS22335 (4602516) 4602516..4602827 - 312 WP_000897305.1 hypothetical protein Toxin
NML18_RS22340 (4603056) 4603056..4603964 + 909 WP_001162704.1 alpha/beta hydrolase -
NML18_RS22345 (4604028) 4604028..4604969 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
NML18_RS22350 (4605014) 4605014..4605451 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
NML18_RS22355 (4605448) 4605448..4606320 - 873 WP_160189261.1 virulence factor BrkB family protein -
NML18_RS22360 (4606314) 4606314..4606913 - 600 WP_001315111.1 glucose-1-phosphatase -
NML18_RS22365 (4607012) 4607012..4607797 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T251747 WP_000897305.1 NZ_CP101269:c4602827-4602516 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT251747 WP_000356397.1 NZ_CP101269:c4602515-4602225 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References