251713

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1835186..1835688 Replicon chromosome
Accession NZ_CP101263
Organism Escherichia coli strain EC21Z-063

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag NML19_RS08900 Protein ID WP_000767829.1
Coordinates 1835434..1835688 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag NML19_RS08895 Protein ID WP_001259255.1
Coordinates 1835186..1835437 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML19_RS08870 (1830363) 1830363..1831430 - 1068 WP_000080102.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
NML19_RS08875 (1831430) 1831430..1832500 - 1071 WP_001099214.1 histidinol-phosphate transaminase -
NML19_RS08880 (1832497) 1832497..1833801 - 1305 WP_001396164.1 histidinol dehydrogenase -
NML19_RS08885 (1833807) 1833807..1834706 - 900 WP_000566782.1 ATP phosphoribosyltransferase -
NML19_RS08890 (1834852) 1834852..1834902 - 51 WP_001364200.1 his operon leader peptide -
NML19_RS08895 (1835186) 1835186..1835437 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
NML19_RS08900 (1835434) 1835434..1835688 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
NML19_RS08905 (1835771) 1835771..1836595 + 825 WP_000754754.1 SDR family oxidoreductase -
NML19_RS08910 (1836641) 1836641..1837570 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
NML19_RS08915 (1837785) 1837785..1837847 + 63 WP_010723108.1 membrane protein YoeI -
NML19_RS08920 (1837837) 1837837..1839195 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
NML19_RS08925 (1839374) 1839374..1840432 + 1059 WP_000492305.1 thiosulfate utilization transporter TsuA/YeeE -
NML19_RS08930 (1840446) 1840446..1840673 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T251713 WP_000767829.1 NZ_CP101263:1835434-1835688 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT251713 WP_001259255.1 NZ_CP101263:1835186-1835437 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References