Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 702328..703021 Replicon chromosome
Accession NZ_CP101263
Organism Escherichia coli strain EC21Z-063

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag NML19_RS03440 Protein ID WP_000415584.1
Coordinates 702328..702624 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag NML19_RS03445 Protein ID WP_000650107.1
Coordinates 702626..703021 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML19_RS03405 (697416) 697416..697730 - 315 WP_000958598.1 putative quinol monooxygenase -
NML19_RS03410 (697761) 697761..698342 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
NML19_RS03415 (698661) 698661..698993 + 333 WP_000917684.1 DUF2645 family protein -
NML19_RS03420 (699039) 699039..700388 - 1350 WP_000673409.1 quorum sensing histidine kinase QseC -
NML19_RS03425 (700385) 700385..701044 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
NML19_RS03430 (701196) 701196..701588 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
NML19_RS03435 (701641) 701641..702123 + 483 WP_000183505.1 GyrI-like domain-containing protein -
NML19_RS03440 (702328) 702328..702624 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
NML19_RS03445 (702626) 702626..703021 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
NML19_RS03450 (703154) 703154..704761 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
NML19_RS03455 (704899) 704899..707157 + 2259 WP_072777792.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T251709 WP_000415584.1 NZ_CP101263:702328-702624 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT251709 WP_000650107.1 NZ_CP101263:702626-703021 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References