Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 196443..196942 Replicon chromosome
Accession NC_015278
Organism Aerococcus urinae ACS-120-V-Col10a

Toxin (Protein)


Gene name yoeB Uniprot ID F2I644
Locus tag HMPREF9243_RS00885 Protein ID WP_013668905.1
Coordinates 196443..196697 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID F2I645
Locus tag HMPREF9243_RS00890 Protein ID WP_013669662.1
Coordinates 196697..196942 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HMPREF9243_RS00870 192724..194217 + 1494 WP_013669445.1 recombinase family protein -
HMPREF9243_RS00875 194305..195204 + 900 WP_081456587.1 type I restriction-modification system subunit M -
HMPREF9243_RS00880 195204..196394 + 1191 WP_013669385.1 restriction endonuclease subunit S -
HMPREF9243_RS00885 196443..196697 - 255 WP_013668905.1 Txe/YoeB family addiction module toxin Toxin
HMPREF9243_RS00890 196697..196942 - 246 WP_013669662.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HMPREF9243_RS00895 196997..197917 - 921 WP_013669497.1 site-specific integrase -
HMPREF9243_RS10550 198649..199086 - 438 Protein_165 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element erm(A) / tet(T) - 147420..197917 50497


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10221.74 Da        Isoelectric Point: 9.9045

>T25169 WP_013668905.1 NC_015278:c196697-196443 [Aerococcus urinae ACS-120-V-Col10a]
MKVHWSRGSVIERDVWKENDRKVYDKIYRLLRAIKEAPYQGLGKPEPLKYDLSGYWSRRLTRQDRLVYRVTDDAIEVLSC
KYHY

Download         Length: 255 bp

>T25169 NC_015278:c196697-196443 [Aerococcus urinae ACS-120-V-Col10a]
ATGAAAGTTCATTGGAGTCGGGGGTCTGTTATCGAACGTGACGTTTGGAAAGAAAATGACCGAAAAGTCTATGATAAGAT
CTATCGCTTATTACGAGCCATCAAAGAAGCCCCCTACCAAGGACTAGGTAAGCCGGAACCTTTAAAATATGATCTATCGG
GTTATTGGTCAAGGCGACTGACTAGACAAGATCGTTTAGTTTACCGTGTCACAGATGACGCGATTGAAGTCCTATCGTGT
AAATACCATTACTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9559.46 Da        Isoelectric Point: 3.9327

>AT25169 WP_013669662.1 NC_015278:c196942-196697 [Aerococcus urinae ACS-120-V-Col10a]
MEVTNYSDFRQNMKKYMDQINEDAIEYTVTSQNGNDVVVMAKSDFDSLMETYHLLSSRANRENLYQAMDELDRGDYEVEE
I

Download         Length: 246 bp

>AT25169 NC_015278:c196942-196697 [Aerococcus urinae ACS-120-V-Col10a]
ATGGAAGTAACCAATTATAGTGATTTCAGACAGAATATGAAGAAATACATGGACCAGATTAATGAAGATGCTATTGAATA
TACTGTAACCTCTCAGAATGGGAATGATGTGGTTGTTATGGCCAAATCAGATTTTGACAGTCTGATGGAGACTTACCATC
TCTTATCGAGCCGCGCCAACCGTGAAAACCTCTACCAAGCCATGGATGAGCTCGATCGTGGCGATTATGAAGTTGAGGAA
ATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E9PJT1

Antitoxin

Source ID Structure
AlphaFold DB A0A1E9PJS7

References