Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3886180..3886438 Replicon chromosome
Accession NZ_CP101251
Organism Escherichia coli strain EC21Z-083

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag NML21_RS18875 Protein ID WP_000809168.1
Coordinates 3886286..3886438 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 3886180..3886237 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML21_RS18855 3881228..3882559 + 1332 Protein_3682 fimbria/pilus outer membrane usher protein -
NML21_RS18860 3882572..3883530 + 959 Protein_3683 fimbrial family protein -
NML21_RS18865 3883569..3884468 - 900 WP_001300855.1 transcriptional activator NhaR -
NML21_RS18870 3884534..3885700 - 1167 WP_000681360.1 Na+/H+ antiporter NhaA -
- 3886180..3886237 - 58 - - Antitoxin
NML21_RS18875 3886286..3886438 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
NML21_RS18880 3886542..3887672 - 1131 WP_001118464.1 molecular chaperone DnaJ -
NML21_RS18885 3887761..3889677 - 1917 WP_000516131.1 molecular chaperone DnaK -
NML21_RS18890 3890054..3890458 + 405 WP_000843559.1 DUF2541 family protein -
NML21_RS18895 3890484..3891197 + 714 WP_001102383.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T251663 WP_000809168.1 NZ_CP101251:3886286-3886438 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT251663 NZ_CP101251:c3886237-3886180 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References