Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3886293..3886551 Replicon chromosome
Accession NZ_CP101245
Organism Escherichia coli strain EC21Z-097

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag NML22_RS18895 Protein ID WP_000809168.1
Coordinates 3886399..3886551 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 3886293..3886350 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML22_RS18875 3881341..3882672 + 1332 Protein_3686 fimbria/pilus outer membrane usher protein -
NML22_RS18880 3882685..3883643 + 959 Protein_3687 fimbrial family protein -
NML22_RS18885 3883682..3884581 - 900 WP_001300855.1 transcriptional activator NhaR -
NML22_RS18890 3884647..3885813 - 1167 WP_000681360.1 Na+/H+ antiporter NhaA -
- 3886293..3886350 - 58 - - Antitoxin
NML22_RS18895 3886399..3886551 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
NML22_RS18900 3886655..3887785 - 1131 WP_001118464.1 molecular chaperone DnaJ -
NML22_RS18905 3887874..3889790 - 1917 WP_000516131.1 molecular chaperone DnaK -
NML22_RS18910 3890167..3890571 + 405 WP_000843559.1 DUF2541 family protein -
NML22_RS18915 3890597..3891310 + 714 WP_001102383.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T251634 WP_000809168.1 NZ_CP101245:3886399-3886551 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT251634 NZ_CP101245:c3886350-3886293 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References