Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 735136..735829 Replicon chromosome
Accession NZ_CP101233
Organism Escherichia coli strain EC21Z-137

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag NML24_RS03625 Protein ID WP_000415584.1
Coordinates 735136..735432 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag NML24_RS03630 Protein ID WP_000650107.1
Coordinates 735434..735829 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML24_RS03595 (730396) 730396..731376 + 981 WP_000019450.1 IS5-like element ISKpn26 family transposase -
NML24_RS03600 (731490) 731490..731801 + 312 WP_212403430.1 DUF2645 family protein -
NML24_RS03605 (731847) 731847..733196 - 1350 WP_000673357.1 quorum sensing histidine kinase QseC -
NML24_RS03610 (733193) 733193..733852 - 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB -
NML24_RS03615 (734004) 734004..734396 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
NML24_RS03620 (734449) 734449..734931 + 483 WP_000183489.1 GyrI-like domain-containing protein -
NML24_RS03625 (735136) 735136..735432 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
NML24_RS03630 (735434) 735434..735829 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
NML24_RS03635 (735962) 735962..737569 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
NML24_RS03640 (737707) 737707..739965 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T251579 WP_000415584.1 NZ_CP101233:735136-735432 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT251579 WP_000650107.1 NZ_CP101233:735434-735829 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References