Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 618639..619438 Replicon chromosome
Accession NZ_CP101233
Organism Escherichia coli strain EC21Z-137

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag NML24_RS03055 Protein ID WP_180469665.1
Coordinates 618639..619103 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID -
Locus tag NML24_RS03060 Protein ID WP_212403239.1
Coordinates 619103..619438 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML24_RS03025 (613640) 613640..614074 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
NML24_RS03030 (614092) 614092..614970 - 879 WP_180469662.1 PTS N-acetylgalactosamine transporter subunit IID -
NML24_RS03035 (614960) 614960..615739 - 780 WP_212403236.1 PTS N-acetylgalactosamine transporter subunit IIC -
NML24_RS03040 (615750) 615750..616223 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
NML24_RS03045 (616246) 616246..617526 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
NML24_RS03050 (617775) 617775..618584 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
NML24_RS03055 (618639) 618639..619103 - 465 WP_180469665.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NML24_RS03060 (619103) 619103..619438 - 336 WP_212403239.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
NML24_RS03065 (619587) 619587..621158 - 1572 WP_032181387.1 galactarate dehydratase -
NML24_RS03070 (621533) 621533..622867 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
NML24_RS03075 (622883) 622883..623653 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 609238..630208 20970


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17793.18 Da        Isoelectric Point: 9.4947

>T251577 WP_180469665.1 NZ_CP101233:c619103-618639 [Escherichia coli]
MDFLQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12443.11 Da        Isoelectric Point: 5.1498

>AT251577 WP_212403239.1 NZ_CP101233:c619438-619103 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGRQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References