Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4168047..4168740 Replicon chromosome
Accession NZ_CP101222
Organism Escherichia coli strain EC21Z-144

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag NML25_RS20010 Protein ID WP_000415584.1
Coordinates 4168444..4168740 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag NML25_RS20005 Protein ID WP_000650107.1
Coordinates 4168047..4168442 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML25_RS19995 (4163911) 4163911..4166169 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
NML25_RS20000 (4166307) 4166307..4167914 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
NML25_RS20005 (4168047) 4168047..4168442 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
NML25_RS20010 (4168444) 4168444..4168740 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
NML25_RS20015 (4168945) 4168945..4169427 - 483 WP_000183505.1 GyrI-like domain-containing protein -
NML25_RS20020 (4169480) 4169480..4169872 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
NML25_RS20025 (4170024) 4170024..4170683 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
NML25_RS20030 (4170680) 4170680..4172029 + 1350 WP_001551658.1 quorum sensing histidine kinase QseC -
NML25_RS20035 (4172078) 4172078..4172407 - 330 WP_001551659.1 DUF2645 family protein -
NML25_RS20040 (4172765) 4172765..4173346 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
NML25_RS20045 (4173377) 4173377..4173691 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T251561 WP_000415584.1 NZ_CP101222:c4168740-4168444 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT251561 WP_000650107.1 NZ_CP101222:c4168442-4168047 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References