Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4838196..4838798 Replicon chromosome
Accession NZ_CP101210
Organism Escherichia coli strain EC21Z-147

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag NML26_RS23580 Protein ID WP_000897305.1
Coordinates 4838487..4838798 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NML26_RS23575 Protein ID WP_000356397.1
Coordinates 4838196..4838486 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML26_RS23555 (4834698) 4834698..4835600 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
NML26_RS23560 (4835597) 4835597..4836232 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
NML26_RS23565 (4836229) 4836229..4837158 + 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
NML26_RS23570 (4837373) 4837373..4837591 - 219 WP_001295676.1 CopG family transcriptional regulator -
NML26_RS23575 (4838196) 4838196..4838486 - 291 WP_000356397.1 NadS family protein Antitoxin
NML26_RS23580 (4838487) 4838487..4838798 - 312 WP_000897305.1 hypothetical protein Toxin
NML26_RS23585 (4839027) 4839027..4839935 + 909 WP_001318161.1 alpha/beta hydrolase -
NML26_RS23590 (4839999) 4839999..4840940 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
NML26_RS23595 (4840985) 4840985..4841422 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
NML26_RS23600 (4841419) 4841419..4842291 - 873 WP_000920762.1 virulence factor BrkB family protein -
NML26_RS23605 (4842285) 4842285..4842884 - 600 WP_001315111.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T251529 WP_000897305.1 NZ_CP101210:c4838798-4838487 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT251529 WP_000356397.1 NZ_CP101210:c4838486-4838196 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References