Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1977518..1978020 Replicon chromosome
Accession NZ_CP101210
Organism Escherichia coli strain EC21Z-147

Toxin (Protein)


Gene name yoeB Uniprot ID V0THH9
Locus tag NML26_RS09440 Protein ID WP_023141665.1
Coordinates 1977766..1978020 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag NML26_RS09435 Protein ID WP_001259255.1
Coordinates 1977518..1977769 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML26_RS09410 (1972696) 1972696..1973763 - 1068 WP_000080136.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
NML26_RS09415 (1973763) 1973763..1974833 - 1071 WP_228253034.1 histidinol-phosphate transaminase -
NML26_RS09420 (1974830) 1974830..1976134 - 1305 WP_029397757.1 histidinol dehydrogenase -
NML26_RS09425 (1976140) 1976140..1977039 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
NML26_RS09430 (1977185) 1977185..1977235 - 51 WP_001364200.1 his operon leader peptide -
NML26_RS09435 (1977518) 1977518..1977769 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
NML26_RS09440 (1977766) 1977766..1978020 + 255 WP_023141665.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
NML26_RS09445 (1978103) 1978103..1978927 + 825 WP_000754758.1 SDR family oxidoreductase -
NML26_RS09450 (1978973) 1978973..1979902 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
NML26_RS09455 (1980117) 1980117..1980179 + 63 WP_010723108.1 membrane protein YoeI -
NML26_RS09460 (1980169) 1980169..1981527 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
NML26_RS09465 (1981706) 1981706..1982764 + 1059 WP_029397759.1 thiosulfate utilization transporter TsuA/YeeE -
NML26_RS09470 (1982778) 1982778..1983005 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10229.67 Da        Isoelectric Point: 7.8733

>T251513 WP_023141665.1 NZ_CP101210:1977766-1978020 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFECKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT251513 WP_001259255.1 NZ_CP101210:1977518-1977769 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0THH9

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References