Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 688604..689403 Replicon chromosome
Accession NZ_CP101210
Organism Escherichia coli strain EC21Z-147

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag NML26_RS03400 Protein ID WP_254825027.1
Coordinates 688604..689068 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag NML26_RS03405 Protein ID WP_001296435.1
Coordinates 689068..689403 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML26_RS03370 (683605) 683605..684039 - 435 WP_000948823.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
NML26_RS03375 (684057) 684057..684935 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
NML26_RS03380 (684925) 684925..685704 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
NML26_RS03385 (685715) 685715..686188 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
NML26_RS03390 (686211) 686211..687491 - 1281 WP_000681938.1 tagatose-bisphosphate aldolase subunit KbaZ -
NML26_RS03395 (687740) 687740..688549 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
NML26_RS03400 (688604) 688604..689068 - 465 WP_254825027.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NML26_RS03405 (689068) 689068..689403 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NML26_RS03410 (689552) 689552..691123 - 1572 WP_001273941.1 galactarate dehydratase -
NML26_RS03415 (691498) 691498..692832 + 1335 WP_000979025.1 galactarate/glucarate/glycerate transporter GarP -
NML26_RS03420 (692848) 692848..693618 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17791.17 Da        Isoelectric Point: 9.4947

>T251509 WP_254825027.1 NZ_CP101210:c689068-688604 [Escherichia coli]
MDFPQRINGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT251509 WP_001296435.1 NZ_CP101210:c689403-689068 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References