Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 22256..22907 Replicon plasmid pEC21Z151-24K
Accession NZ_CP101202
Organism Escherichia coli strain EC21Z-151

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NML27_RS26255 Protein ID WP_094283547.1
Coordinates 22256..22606 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NML27_RS26260 Protein ID WP_094283546.1
Coordinates 22608..22907 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML27_RS26220 (NML27_26215) 17381..19108 + 1728 WP_094283553.1 type IV secretory system conjugative DNA transfer family protein -
NML27_RS26225 (NML27_26220) 19118..19852 + 735 WP_094283552.1 MobC family replication-relaxation protein -
NML27_RS26230 (NML27_26225) 19856..20335 + 480 WP_094283551.1 thermonuclease family protein -
NML27_RS26235 (NML27_26230) 20332..20709 + 378 WP_094283550.1 hypothetical protein -
NML27_RS26240 (NML27_26235) 20678..20941 + 264 WP_094283549.1 PilI type IV pilus biogenesis protein -
NML27_RS26245 (NML27_26240) 20973..21206 - 234 WP_000024515.1 hypothetical protein -
NML27_RS26250 (NML27_26245) 21246..21944 - 699 WP_249540332.1 ParA family protein -
NML27_RS26255 (NML27_26250) 22256..22606 + 351 WP_094283547.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NML27_RS26260 (NML27_26255) 22608..22907 + 300 WP_094283546.1 helix-turn-helix transcriptional regulator Antitoxin
NML27_RS26265 (NML27_26260) 22914..23024 + 111 Protein_32 transcriptional regulator -
NML27_RS26270 (NML27_26265) 23099..23338 - 240 WP_094283545.1 hypothetical protein -
NML27_RS26275 (NML27_26270) 23328..23585 - 258 WP_024192529.1 hypothetical protein -
NML27_RS26280 (NML27_26275) 23622..24164 - 543 WP_094283544.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..24263 24263


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(17-87)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13408.35 Da        Isoelectric Point: 6.9806

>T251502 WP_094283547.1 NZ_CP101202:22256-22606 [Escherichia coli]
MWNVVTTDIFDAWFLTQNEDLRESVYEAMGLLEKFGPTLGRPYVDTLNGSDFANMKELRVQYKGSPVRAFFAFDPTRNAI
VLCAGDKTGLNEKRFYKDMIKLADSEYRKHLAKLEK

Download         Length: 351 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10986.70 Da        Isoelectric Point: 8.5545

>AT251502 WP_094283546.1 NZ_CP101202:22608-22907 [Escherichia coli]
MGTYRELLAKESPEMQARVAERVEKASVQIALSALRDELNISQTELATMMGVKQPSVARMEQTDNDPRISTLKRYVKALG
GELSLDVTLPTGKRVAFHL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References