Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4883179..4883781 Replicon chromosome
Accession NZ_CP101197
Organism Escherichia coli strain EC21Z-151

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag NML27_RS23355 Protein ID WP_000897305.1
Coordinates 4883470..4883781 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NML27_RS23350 Protein ID WP_000356395.1
Coordinates 4883179..4883469 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML27_RS23315 (4878803) 4878803..4879705 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
NML27_RS23320 (4879702) 4879702..4880337 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
NML27_RS23325 (4880334) 4880334..4881263 + 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
NML27_RS23330 (4881445) 4881445..4881687 - 243 WP_001309881.1 CopG family transcriptional regulator -
NML27_RS23335 (4881906) 4881906..4882124 - 219 WP_001295676.1 CopG family transcriptional regulator -
NML27_RS23340 (4882543) 4882543..4882821 - 279 WP_001315112.1 hypothetical protein -
NML27_RS23345 (4882873) 4882873..4883094 - 222 WP_001550354.1 hypothetical protein -
NML27_RS23350 (4883179) 4883179..4883469 - 291 WP_000356395.1 NadS family protein Antitoxin
NML27_RS23355 (4883470) 4883470..4883781 - 312 WP_000897305.1 hypothetical protein Toxin
NML27_RS23360 (4884010) 4884010..4884918 + 909 WP_001550353.1 alpha/beta hydrolase -
NML27_RS23365 (4885086) 4885086..4886000 - 915 WP_233304549.1 transposase -
NML27_RS23370 (4886013) 4886013..4886900 - 888 Protein_4564 hypothetical protein -
NML27_RS23375 (4887316) 4887316..4888257 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
NML27_RS23380 (4888302) 4888302..4888739 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T251492 WP_000897305.1 NZ_CP101197:c4883781-4883470 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10869.46 Da        Isoelectric Point: 10.8907

>AT251492 WP_000356395.1 NZ_CP101197:c4883469-4883179 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRHPSRTFEVDAMKIKEIRRASGLSQSKFAELISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References