Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 759243..759936 Replicon chromosome
Accession NZ_CP101197
Organism Escherichia coli strain EC21Z-151

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag NML27_RS03660 Protein ID WP_000415584.1
Coordinates 759243..759539 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag NML27_RS03665 Protein ID WP_000650107.1
Coordinates 759541..759936 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NML27_RS03625 (754292) 754292..754606 - 315 WP_000958598.1 putative quinol monooxygenase -
NML27_RS03630 (754637) 754637..755218 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
NML27_RS03635 (755576) 755576..755905 + 330 WP_001551659.1 DUF2645 family protein -
NML27_RS03640 (755954) 755954..757303 - 1350 WP_001551658.1 quorum sensing histidine kinase QseC -
NML27_RS03645 (757300) 757300..757959 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
NML27_RS03650 (758111) 758111..758503 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
NML27_RS03655 (758556) 758556..759038 + 483 WP_000183505.1 GyrI-like domain-containing protein -
NML27_RS03660 (759243) 759243..759539 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
NML27_RS03665 (759541) 759541..759936 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
NML27_RS03670 (760069) 760069..761676 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
NML27_RS03675 (761814) 761814..764072 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - rfaE 686974..764072 77098


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T251472 WP_000415584.1 NZ_CP101197:759243-759539 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT251472 WP_000650107.1 NZ_CP101197:759541-759936 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References