Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 4791481..4791989 Replicon chromosome
Accession NZ_CP101140
Organism Streptomyces cavourensis strain 2BA6PG

Toxin (Protein)


Gene name yoeB Uniprot ID N0CS17
Locus tag NF554_RS20605 Protein ID WP_015609077.1
Coordinates 4791481..4791741 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag NF554_RS20610 Protein ID WP_114931509.1
Coordinates 4791738..4791989 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NF554_RS20580 4786980..4787477 - 498 WP_119824893.1 DinB family protein -
NF554_RS20585 4787519..4788235 - 717 WP_119824891.1 class I SAM-dependent methyltransferase -
NF554_RS20590 4788342..4789019 + 678 WP_240324025.1 XRE family transcriptional regulator -
NF554_RS20595 4789058..4789801 - 744 WP_162888370.1 hypothetical protein -
NF554_RS20600 4790048..4791493 + 1446 WP_119824885.1 acyltransferase family protein -
NF554_RS20605 4791481..4791741 - 261 WP_015609077.1 Txe/YoeB family addiction module toxin Toxin
NF554_RS20610 4791738..4791989 - 252 WP_114931509.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
NF554_RS20615 4792123..4793946 + 1824 WP_119824883.1 ABC-F family ATP-binding cassette domain-containing protein -
NF554_RS20620 4794252..4796225 + 1974 WP_162888369.1 PQQ-binding-like beta-propeller repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10452.79 Da        Isoelectric Point: 9.4245

>T251455 WP_015609077.1 NZ_CP101140:c4791741-4791481 [Streptomyces cavourensis]
VKFVWDQSSWDDYVWWQNQDRKILKRINTLLQDIARNGNEGMGKPEPLKHGFQGYWSRRITDEHRLIYKVVDDEVRVAAC
RYHYGR

Download         Length: 261 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9313.44 Da        Isoelectric Point: 4.6892

>AT251455 WP_114931509.1 NZ_CP101140:c4791989-4791738 [Streptomyces cavourensis]
MRTMTYTESRAKYAETLSAVVNDREEVVVTRAGHEPVVIVALDEYESLKETAYQLRSPENARRLLASIERLESGGGTVRE
LAE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB N0CS17

Antitoxin

Source ID Structure

References