251454

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2513850..2514554 Replicon chromosome
Accession NZ_CP101140
Organism Streptomyces cavourensis strain 2BA6PG

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag NF554_RS10180 Protein ID WP_093755904.1
Coordinates 2514195..2514554 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NF554_RS10175 Protein ID WP_019762572.1
Coordinates 2513850..2514188 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NF554_RS10160 2509614..2510141 - 528 WP_119826613.1 DUF4265 domain-containing protein -
NF554_RS10165 2510406..2512294 + 1889 Protein_2015 coagulation factor 5/8 type domain-containing protein -
NF554_RS10170 2512448..2513744 - 1297 Protein_2016 GNAT family N-acetyltransferase -
NF554_RS10175 2513850..2514188 - 339 WP_019762572.1 XRE family transcriptional regulator Antitoxin
NF554_RS10180 2514195..2514554 - 360 WP_093755904.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NF554_RS10185 2514687..2516972 - 2286 WP_254811757.1 hypothetical protein -
NF554_RS10190 2517148..2517780 - 633 WP_119826607.1 DUF6113 family protein -
NF554_RS10195 2517777..2518796 - 1020 WP_119826605.1 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha- D-glucopyranoside deacetylase -
NF554_RS10200 2518925..2519119 - 195 WP_018490263.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(19-112)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-95)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13034.81 Da        Isoelectric Point: 9.6195

>T251454 WP_093755904.1 NZ_CP101140:c2514554-2514195 [Streptomyces cavourensis]
MQFRVIVVEPARSWLHGLRQHDRDTLLQVTAAIDVLQREGPALGRPLVDRVAGATLANLKELRPGSSGSSEVRILFVFDS
ARNAVILVGGDKSGSWSGWYRTAIKVAEDAYEAYRDGKG

Download         Length: 360 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 12076.66 Da        Isoelectric Point: 4.9567

>AT251454 WP_019762572.1 NZ_CP101140:c2514188-2513850 [Streptomyces cavourensis]
VSAGRKAADAVGWDDLKDEFDLSADETREVERRAALLLSEVRAHRLAEVRKRQQMTQAAVAKVLGVTQGRVSAIEKGEIN
RSEVETLAAYVAALGGQLKLVADFGDETLVLG

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References