Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 504929..505443 Replicon chromosome
Accession NZ_CP101137
Organism Streptomyces sp. M92

Toxin (Protein)


Gene name yoeB Uniprot ID A0A1Q5D2H4
Locus tag M6G08_RS02270 Protein ID WP_073722360.1
Coordinates 505189..505443 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1Q5D2D7
Locus tag M6G08_RS02265 Protein ID WP_043373664.1
Coordinates 504929..505192 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M6G08_RS02255 (M6G08_02265) 500904..501767 + 864 WP_272585500.1 phosphatase PAP2 family protein -
M6G08_RS02260 (M6G08_02270) 501777..504779 - 3003 WP_272585501.1 bifunctional [glutamine synthetase] adenylyltransferase/[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase -
M6G08_RS02265 (M6G08_02275) 504929..505192 + 264 WP_043373664.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
M6G08_RS02270 (M6G08_02280) 505189..505443 + 255 WP_073722360.1 Txe/YoeB family addiction module toxin Toxin
M6G08_RS02275 (M6G08_02285) 505497..505943 + 447 WP_073722362.1 VOC family protein -
M6G08_RS02280 (M6G08_02290) 505948..507702 - 1755 WP_272585503.1 NAD+ synthase -
M6G08_RS02285 (M6G08_02295) 507786..508412 - 627 WP_272585504.1 DUF305 domain-containing protein -
M6G08_RS02290 (M6G08_02300) 508409..509083 - 675 WP_272585505.1 DUF3105 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9943.21 Da        Isoelectric Point: 9.3934

>T251453 WP_073722360.1 NZ_CP101137:505189-505443 [Streptomyces sp. M92]
VRIAFTSHGWEDYVHWAESDRKMTRRINRLLADTARDPFKGIGKPEPLKGDLSGYWSRRIDDTHRLVYKPGDDELIVVQA
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9802.90 Da        Isoelectric Point: 4.8784

>AT251453 WP_043373664.1 NZ_CP101137:504929-505192 [Streptomyces sp. M92]
MSITASEARQNLFPLIEQVNEDHAPVHITSRKGNAVLMSEEDFTAWTETVHLLRSPRNARRLLDSIAEAEAGEARHRELI
DPDAERA

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q5D2H4

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q5D2D7

References