Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 6479582..6480174 Replicon chromosome
Accession NZ_CP101125
Organism Pseudomonas nunensis strain In5

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NK667_RS28495 Protein ID WP_054617026.1
Coordinates 6479582..6479860 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID A0A6L5BL31
Locus tag NK667_RS28500 Protein ID WP_054617025.1
Coordinates 6479869..6480174 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NK667_RS28475 (NK667_28475) 6475673..6476887 + 1215 WP_054617029.1 aldose 1-epimerase family protein -
NK667_RS28480 (NK667_28480) 6476940..6477242 - 303 WP_054048502.1 hypothetical protein -
NK667_RS28485 (NK667_28485) 6477293..6478786 - 1494 WP_054617028.1 YifB family Mg chelatase-like AAA ATPase -
NK667_RS28490 (NK667_28490) 6479162..6479332 - 171 WP_177331480.1 hypothetical protein -
NK667_RS28495 (NK667_28495) 6479582..6479860 + 279 WP_054617026.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NK667_RS28500 (NK667_28500) 6479869..6480174 + 306 WP_054617025.1 HigA family addiction module antitoxin Antitoxin
NK667_RS28505 (NK667_28505) 6480228..6480755 - 528 WP_054617024.1 Bro-N domain-containing protein -
NK667_RS28510 (NK667_28510) 6481199..6481459 - 261 WP_054048512.1 accessory factor UbiK family protein -
NK667_RS28515 (NK667_28515) 6481875..6482213 + 339 WP_002555808.1 P-II family nitrogen regulator -
NK667_RS28520 (NK667_28520) 6482249..6483586 + 1338 WP_054048514.1 ammonium transporter -
NK667_RS28525 (NK667_28525) 6483800..6484225 + 426 WP_054048516.1 secondary thiamine-phosphate synthase enzyme YjbQ -
NK667_RS28530 (NK667_28530) 6484328..6484651 + 324 WP_054617023.1 transcriptional regulator SutA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10578.27 Da        Isoelectric Point: 8.5043

>T251447 WP_054617026.1 NZ_CP101125:6479582-6479860 [Pseudomonas nunensis]
MIVSFKCSETEYLFRNGKTRMWSALLNVVERKLTMLDAAAVLMDLRSPPGNRLEALEGSRKGQYSIRINAQWRICFVWGL
SGPENVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11218.94 Da        Isoelectric Point: 6.4556

>AT251447 WP_054617025.1 NZ_CP101125:6479869-6480174 [Pseudomonas nunensis]
MTKNGMRPVHPGEILKEEYLEPLSLTAAALARALSVSTPTVNDIVLQRRGVSADMALRLSICLDTTPEFWLNLQSTYDLR
KAEIERGAAIRDQVERLAHCA

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6L5BL31

References