Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 6026272..6026935 Replicon chromosome
Accession NZ_CP101125
Organism Pseudomonas nunensis strain In5

Toxin (Protein)


Gene name higB Uniprot ID A0A6L5BTX6
Locus tag NK667_RS26505 Protein ID WP_054616608.1
Coordinates 6026272..6026637 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A423JKM8
Locus tag NK667_RS26510 Protein ID WP_054616609.1
Coordinates 6026630..6026935 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NK667_RS26485 (NK667_26485) 6021362..6021880 - 519 WP_054616604.1 GNAT family N-acetyltransferase -
NK667_RS26490 (NK667_26490) 6021898..6023994 - 2097 WP_054616605.1 biotin/lipoyl-binding protein -
NK667_RS26495 (NK667_26495) 6023995..6025314 - 1320 WP_054616606.1 HlyD family efflux transporter periplasmic adaptor subunit -
NK667_RS26500 (NK667_26500) 6025311..6026093 - 783 WP_054616607.1 efflux RND transporter periplasmic adaptor subunit -
NK667_RS26505 (NK667_26505) 6026272..6026637 + 366 WP_054616608.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NK667_RS26510 (NK667_26510) 6026630..6026935 + 306 WP_054616609.1 XRE family transcriptional regulator Antitoxin
NK667_RS26515 (NK667_26515) 6027040..6027597 - 558 WP_054616610.1 hypothetical protein -
NK667_RS26520 (NK667_26520) 6027709..6029241 - 1533 WP_054616611.1 efflux transporter outer membrane subunit -
NK667_RS26525 (NK667_26525) 6029238..6030302 - 1065 WP_054616612.1 HlyD family secretion protein -
NK667_RS26530 (NK667_26530) 6030329..6031864 - 1536 WP_054616613.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-86)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13826.29 Da        Isoelectric Point: 5.5128

>T251445 WP_054616608.1 NZ_CP101125:6026272-6026637 [Pseudomonas nunensis]
MNWDIEYTDEFGDWWTDLSESEQSSVAASVKLLGQFGPGLRFPHSSGINGSRHGHLRELRVQHAGRPYRILYAFDPKRCA
LLLIGGDKTGQDRWYEVNVPLADQLYDEHLDTLRKEGHNDG

Download         Length: 366 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11465.22 Da        Isoelectric Point: 6.7278

>AT251445 WP_054616609.1 NZ_CP101125:6026630-6026935 [Pseudomonas nunensis]
MAKKFAELEARMTPESRALADSIYEQHIKEMPLHELRQAKALSQATLAETLHINQAAISKMERRTDMYISTLRNYIRAMG
GELEIIATFPDGQIKIENFAG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L5BTX6

Antitoxin

Source ID Structure
AlphaFold DB A0A423JKM8

References