251440

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2410185..2410708 Replicon chromosome
Accession NZ_CP101124
Organism Staphylococcus aureus subsp. aureus RN4220

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag NMK49_RS11880 Protein ID WP_000074048.1
Coordinates 2410185..2410451 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag NMK49_RS11885 Protein ID WP_000587616.1
Coordinates 2410451..2410708 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMK49_RS11860 2405492..2406679 - 1188 WP_000026194.1 MFS transporter -
NMK49_RS11865 2407075..2407851 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
NMK49_RS11870 2407844..2408506 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
NMK49_RS11875 2408754..2409830 - 1077 WP_001076671.1 M42 family metallopeptidase -
NMK49_RS11880 2410185..2410451 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
NMK49_RS11885 2410451..2410708 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NMK49_RS11890 2411067..2411522 + 456 WP_000732082.1 DUF1307 domain-containing protein -
NMK49_RS11895 2411690..2413267 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
NMK49_RS11900 2413462..2414211 + 750 WP_000072443.1 CPBP family lipoprotein N-acylation protein LnsB -
NMK49_RS11905 2414435..2415628 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T251440 WP_000074048.1 NZ_CP101124:c2410451-2410185 [Staphylococcus aureus subsp. aureus RN4220]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT251440 WP_000587616.1 NZ_CP101124:c2410708-2410451 [Staphylococcus aureus subsp. aureus RN4220]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References