Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2378684..2378868 Replicon chromosome
Accession NZ_CP101124
Organism Staphylococcus aureus subsp. aureus RN4220

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag NMK49_RS11740 Protein ID WP_000482650.1
Coordinates 2378761..2378868 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2378684..2378744 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMK49_RS11725 2374214..2374381 - 168 WP_001790576.1 hypothetical protein -
NMK49_RS11730 2374612..2376345 - 1734 WP_000486494.1 ABC transporter ATP-binding protein -
NMK49_RS11735 2376370..2378133 - 1764 WP_001064838.1 ABC transporter ATP-binding protein -
- 2378684..2378744 + 61 - - Antitoxin
NMK49_RS11740 2378761..2378868 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
NMK49_RS11745 2379002..2379388 - 387 WP_000779358.1 flippase GtxA -
NMK49_RS11750 2379656..2380798 + 1143 WP_001176863.1 glycerate kinase -
NMK49_RS11755 2380858..2381517 + 660 WP_000831298.1 membrane protein -
NMK49_RS11760 2381699..2382910 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
NMK49_RS11765 2383033..2383506 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T251439 WP_000482650.1 NZ_CP101124:c2378868-2378761 [Staphylococcus aureus subsp. aureus RN4220]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

Antitoxin


Download         Length: 61 bp

>AT251439 NZ_CP101124:2378684-2378744 [Staphylococcus aureus subsp. aureus RN4220]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References