251438

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2353332..2353849 Replicon chromosome
Accession NZ_CP101124
Organism Staphylococcus aureus subsp. aureus RN4220

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag NMK49_RS11605 Protein ID WP_000113262.1
Coordinates 2353332..2353598 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag NMK49_RS11610 Protein ID WP_000584499.1
Coordinates 2353598..2353849 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMK49_RS11575 2348758..2349294 - 537 WP_000169315.1 GNAT family N-acetyltransferase -
NMK49_RS11580 2349527..2350351 - 825 WP_000572040.1 formate/nitrite transporter family protein -
NMK49_RS11585 2350568..2350750 - 183 WP_000230294.1 hypothetical protein -
NMK49_RS11590 2350834..2351301 - 468 WP_000153344.1 SRPBCC domain-containing protein -
NMK49_RS11595 2351487..2353037 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
NMK49_RS11600 2353226..2353297 - 72 Protein_2237 hypothetical protein -
NMK49_RS11605 2353332..2353598 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
NMK49_RS11610 2353598..2353849 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NMK49_RS11615 2354014..2354115 - 102 WP_001791744.1 hypothetical protein -
NMK49_RS11620 2354122..2354721 - 600 WP_000162813.1 DsbA family protein -
NMK49_RS11625 2354740..2355102 - 363 WP_000819843.1 DUF4467 domain-containing protein -
NMK49_RS11630 2355357..2356607 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
NMK49_RS11635 2356704..2357435 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
NMK49_RS11640 2357432..2358151 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T251438 WP_000113262.1 NZ_CP101124:c2353598-2353332 [Staphylococcus aureus subsp. aureus RN4220]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT251438 WP_000584499.1 NZ_CP101124:c2353849-2353598 [Staphylococcus aureus subsp. aureus RN4220]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References