Detailed information of TA system TA025143

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1059380..1060074
• Replicon: chromosome
• Accession: NC_015224
• Organism: Yersinia enterocolitica subsp. palearctica 105.5R(r)

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: A0A7U7FJ92
• Locus tag: YE105_RS04680
• Protein ID: WP_005166025.1
• Coordinates: 1059380..1059676 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: A0A7U7IQA2
• Locus tag: YE105_RS04685
• Protein ID: WP_005166024.1
• Coordinates: 1059676..1060074 (+)
• Length: 133 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YE105_RS04660	1054643..1056520	+	1878	WP_013649345.1	site-specific integrase	-
YE105_RS04665	1056504..1057229	-	726	WP_013649170.1	IS21-like element ISYen2A/ISYen2B family helper ATPase IstB	-
YE105_RS04670	1057216..1058724	-	1509	WP_005180650.1	IS21-like element ISYen2A family transposase	-
YE105_RS04675	1058861..1059223	+	363	WP_005166026.1	helix-turn-helix domain-containing protein	-
YE105_RS04680	1059380..1059676	+	297	WP_005166025.1	type II toxin-antitoxin system MqsR family toxin	Toxin
YE105_RS04685	1059676..1060074	+	399	WP_005166024.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
YE105_RS04690	1060181..1061383	-	1203	WP_013649347.1	IS256 family transposase	-
YE105_RS04695	1061526..1061726	-	201	WP_005166614.1	AlpA family transcriptional regulator	-
YE105_RS04700	1061744..1062580	+	837	Protein_893	Fic family protein	-
YE105_RS04705	1062951..1063346	+	396	WP_005166615.1	SgcJ/EcaC family oxidoreductase	-
YE105_RS04710	1063429..1064673	+	1245	WP_005166619.1	sensor domain-containing diguanylate cyclase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	1056504..1066110	9606

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-97)

Antitoxin

• Cro/C1-type helix-turn-helix domain (75-128)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11322.18 Da
• Isoelectric Point: 7.7766

>T25143 WP_005166025.1 NC_015224:1059380-1059676 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
MEKRTPHTRLLKVKELVLKGNVKSTRTARDGAEELGLSFRDMCDVVCELTSADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLIVSFKEL

Nucleotide

• Length: 297 bp

>T25143 NC_015224:1059380-1059676 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
ATGGAGAAACGGACTCCGCATACTCGTTTACTAAAAGTAAAAGAATTGGTATTGAAAGGGAATGTTAAATCGACTCGAAC
TGCCAGAGATGGCGCTGAAGAGCTGGGGCTGAGTTTTAGGGATATGTGTGATGTAGTTTGCGAACTGACTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACGATTTGGCAGGATGTTTACCGCCCCATGCTTTCGTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGATTGTCTCGTTTAAGGAGCTTTAA

Antitoxin

Protein

• Length: 133 a.a.
• Molecular weight: 14716.19 Da
• Isoelectric Point: 8.8165

>AT25143 WP_005166024.1 NC_015224:1059676-1060074 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
MMKCPVCGGAELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETIMTEAESDTYAAKTMLLRKMVNTESIAPAYIVQVRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHRSTIKLLQVLDKYPELLNEIR

Nucleotide

• Length: 399 bp

>AT25143 NC_015224:1059676-1060074 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
ATGATGAAATGCCCAGTTTGTGGTGGTGCAGAATTAATCCACGAAGCGCGTGACGTCCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGACAACATTGCCCGGCATGCGGTGAAACAATCATGACTGAAGCTGAGTCCGATACCT
ATGCCGCAAAAACAATGCTTTTGCGAAAAATGGTTAATACAGAATCGATTGCACCCGCATATATTGTGCAGGTGCGAAAA
AAATTGGGTCTAAACCAGCGGGAAGCTAGTGAGATTTTTGGCGGTGGAGTGAATGCTTTTTCGCGTTACGAAAAGGGTAA
GGCGTTGCCACACCGTTCAACGATAAAATTGTTGCAAGTGCTTGATAAATATCCTGAGTTATTGAATGAAATCAGGTAG

Structures

Toxin

• AlphaFold DB: A0A7U7FJ92

Antitoxin

• AlphaFold DB: A0A7U7IQA2