Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2478657..2479174 Replicon chromosome
Accession NZ_CP101123
Organism Staphylococcus aureus strain MN8

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag NLA26_RS12265 Protein ID WP_000251928.1
Coordinates 2478908..2479174 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag NLA26_RS12260 Protein ID WP_000584497.1
Coordinates 2478657..2478908 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLA26_RS12230 (2474357) 2474357..2475076 + 720 WP_000479573.1 amino acid ABC transporter permease -
NLA26_RS12235 (2475073) 2475073..2475804 + 732 WP_000615467.1 amino acid ABC transporter ATP-binding protein -
NLA26_RS12240 (2475901) 2475901..2477151 - 1251 WP_001012237.1 FemA/FemB family glycyltransferase FmhA -
NLA26_RS12245 (2477406) 2477406..2477768 + 363 WP_000819843.1 DUF4467 domain-containing protein -
NLA26_RS12250 (2477787) 2477787..2478386 + 600 WP_000162804.1 DsbA family protein -
NLA26_RS12255 (2478393) 2478393..2478493 + 101 Protein_2382 hypothetical protein -
NLA26_RS12260 (2478657) 2478657..2478908 + 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NLA26_RS12265 (2478908) 2478908..2479174 + 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
NLA26_RS12270 (2479467) 2479467..2481014 + 1548 WP_000727771.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
NLA26_RS12275 (2481200) 2481200..2481667 + 468 WP_000153340.1 SRPBCC domain-containing protein -
NLA26_RS12280 (2481753) 2481753..2481935 + 183 WP_000079140.1 hypothetical protein -
NLA26_RS12285 (2482138) 2482138..2482962 + 825 WP_000594640.1 formate/nitrite transporter family protein -
NLA26_RS12290 (2483430) 2483430..2483966 + 537 WP_000024292.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T251426 WP_000251928.1 NZ_CP101123:2478908-2479174 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT251426 WP_000584497.1 NZ_CP101123:2478657-2478908 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A170NWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References