Detailed information of TA system TA251422

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 970254..970833
• Replicon: chromosome
• Accession: NZ_CP101123
• Organism: Staphylococcus aureus strain MN8

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: NLA26_RS04970
• Protein ID: WP_001025401.1
• Coordinates: 970588..970833 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	970254..970619 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NLA26_RS04930 (966996)	966996..967552	-	557	Protein_942	DUF2815 family protein	-
NLA26_RS04935 (967578)	967578..968744	-	1167	WP_000762529.1	DUF2800 domain-containing protein	-
NLA26_RS04940 (968741)	968741..969103	-	363	WP_000985972.1	hypothetical protein	-
NLA26_RS04945 (969118)	969118..969441	-	324	WP_000174999.1	hypothetical protein	-
NLA26_RS04950 (969520)	969520..969681	-	162	WP_001285948.1	DUF1270 domain-containing protein	-
NLA26_RS04955 (969694)	969694..969957	-	264	WP_001124194.1	helix-turn-helix domain-containing protein	-
NLA26_RS04960 (969984)	969984..970199	-	216	WP_001097552.1	hypothetical protein	-
NLA26_RS04965 (970254)	970254..970619	+	366	WP_001128433.1	hypothetical protein	Antitoxin
NLA26_RS04970 (970588)	970588..970833	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
NLA26_RS04975 (970900)	970900..971280	+	381	WP_000773059.1	DUF2513 domain-containing protein	-
NLA26_RS04980 (971267)	971267..971464	-	198	WP_001148860.1	hypothetical protein	-
NLA26_RS04985 (971534)	971534..971746	+	213	WP_000362644.1	hypothetical protein	-
NLA26_RS04990 (971787)	971787..971936	-	150	WP_000771849.1	hypothetical protein	-
NLA26_RS04995 (971951)	971951..972394	-	444	WP_000435362.1	hypothetical protein	-
NLA26_RS05000 (972412)	972412..972636	-	225	WP_000333485.1	DUF739 family protein	-
NLA26_RS05005 (972798)	972798..973178	+	381	WP_001089477.1	helix-turn-helix domain-containing protein	-
NLA26_RS05010 (973200)	973200..973658	+	459	WP_000521395.1	hypothetical protein	-
NLA26_RS05015 (973676)	973676..974110	+	435	WP_000755719.1	hypothetical protein	-
NLA26_RS05020 (974139)	974139..974534	+	396	WP_000449656.1	hypothetical protein	-
NLA26_RS05025 (974733)	974733..975356	-	624	WP_001166482.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	931831..994321	62490

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T251422 WP_001025401.1 NZ_CP101123:c970833-970588 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT251422 NZ_CP101123:970254-970619 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin