Detailed information of TA system TA251417

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 20060..20367
• Replicon: chromosome
• Accession: NZ_CP101123
• Organism: Staphylococcus aureus strain MN8

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: NLA26_RS00110
• Protein ID: WP_011447039.1
• Coordinates: 20060..20236 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	20228..20367 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NLA26_RS00090	17841..17993	+	153	WP_001153681.1	hypothetical protein	-
NLA26_RS00095	18040..18327	+	288	WP_001040259.1	hypothetical protein	-
NLA26_RS00100	18383..18757	+	375	WP_000340977.1	hypothetical protein	-
NLA26_RS00105	19178..19951	+	774	WP_000750406.1	staphylococcal enterotoxin type A	-
NLA26_RS00110	20060..20236	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	20228..20367	-	140	NuclAT_0	-	Antitoxin
-	20228..20367	-	140	NuclAT_0	-	Antitoxin
-	20228..20367	-	140	NuclAT_0	-	Antitoxin
-	20228..20367	-	140	NuclAT_0	-	Antitoxin
NLA26_RS00115	20289..20396	-	108	WP_001791821.1	hypothetical protein	-
NLA26_RS00120	20448..20702	+	255	WP_000611512.1	phage holin	-
NLA26_RS00125	20714..21469	+	756	WP_000861038.1	CHAP domain-containing protein	-
NLA26_RS00130	21660..22151	+	492	WP_000919350.1	staphylokinase	-
NLA26_RS00135	22801..23136	+	336	Protein_26	SH3 domain-containing protein	-
NLA26_RS00140	23231..23680	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
NLA26_RS00145	24366..24716	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
NLA26_RS00150	24769..25029	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sea / sak / chp / scn	1..24716	24715

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T251417 WP_011447039.1 NZ_CP101123:20060-20236 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 140 bp

>AT251417 NZ_CP101123:c20367-20228 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin