Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4664217..4664947 Replicon chromosome
Accession NZ_CP100765
Organism Serratia nematodiphila strain SASK3000

Toxin (Protein)


Gene name higB Uniprot ID A0A8B4GR63
Locus tag NLX84_RS22190 Protein ID WP_004937033.1
Coordinates 4664217..4664528 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NLX84_RS22195 Protein ID WP_004937031.1
Coordinates 4664525..4664947 (+) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLX84_RS22160 (NLX84_22160) 4659544..4660269 + 726 WP_254734378.1 LPS export ABC transporter ATP-binding protein -
NLX84_RS22165 (NLX84_22165) 4660322..4661755 + 1434 WP_021505109.1 RNA polymerase factor sigma-54 -
NLX84_RS22170 (NLX84_22170) 4661779..4662066 + 288 WP_004937038.1 ribosome hibernation promoting factor -
NLX84_RS22175 (NLX84_22175) 4662222..4662683 + 462 WP_016930212.1 PTS IIA-like nitrogen regulatory protein PtsN -
NLX84_RS22180 (NLX84_22180) 4662811..4663665 + 855 WP_015379177.1 RNase adapter RapZ -
NLX84_RS22185 (NLX84_22185) 4663662..4663934 + 273 WP_004937034.1 PTS phosphocarrier protein NPr -
NLX84_RS22190 (NLX84_22190) 4664217..4664528 + 312 WP_004937033.1 type II toxin-antitoxin system HigB family toxin Toxin
NLX84_RS22195 (NLX84_22195) 4664525..4664947 + 423 WP_004937031.1 helix-turn-helix domain-containing protein Antitoxin
NLX84_RS22200 (NLX84_22200) 4664952..4666868 - 1917 WP_033632012.1 PRD domain-containing protein -
NLX84_RS22205 (NLX84_22205) 4666920..4668134 - 1215 WP_254734379.1 lactonase family protein -
NLX84_RS22210 (NLX84_22210) 4668222..4668962 - 741 WP_033632010.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(81-135)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12289.14 Da        Isoelectric Point: 10.0957

>T251404 WP_004937033.1 NZ_CP100765:4664217-4664528 [Serratia nematodiphila]
MHIISREPFNNATKQYPNEATALEAIYKALRRGEFRTPDELKALFPSLDRMKYKEKWWVIDVGGNHLRILFFASFETQKV
FIKHIVSHAEYDKLMQHYRRSSS

Download         Length: 312 bp

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15784.13 Da        Isoelectric Point: 5.2139

>AT251404 WP_004937031.1 NZ_CP100765:4664525-4664947 [Serratia nematodiphila]
MITDAIKAADALLRAVPLLQGSRAQQDYREALELVEYLLENDERHPLIDMLAKKIAEYEDNSAEFTAFNQHIAQLPQGVA
ALRVLMEQHQLSQSDFEHEIGKKSLVNQILNGKRSLTIPHIMALAKRFNLPPALFLPEAD

Download         Length: 423 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4GR63

Antitoxin

Source ID Structure

References