Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4190831..4191483 Replicon chromosome
Accession NZ_CP100765
Organism Serratia nematodiphila strain SASK3000

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NLX84_RS19920 Protein ID WP_048324788.1
Coordinates 4190831..4191175 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A086GAN0
Locus tag NLX84_RS19925 Protein ID WP_004931828.1
Coordinates 4191181..4191483 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLX84_RS19910 (NLX84_19910) 4187173..4189431 - 2259 WP_135638586.1 molybdopterin guanine dinucleotide-containing S/N-oxide reductase -
NLX84_RS19915 (NLX84_19915) 4189652..4190671 + 1020 WP_135638588.1 HTH-type transcriptional regulator GalR -
NLX84_RS19920 (NLX84_19920) 4190831..4191175 + 345 WP_048324788.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NLX84_RS19925 (NLX84_19925) 4191181..4191483 + 303 WP_004931828.1 XRE family transcriptional regulator Antitoxin
NLX84_RS19930 (NLX84_19930) 4191511..4192773 - 1263 WP_060560144.1 diaminopimelate decarboxylase -
NLX84_RS19935 (NLX84_19935) 4192907..4193830 + 924 WP_021505677.1 LysR family transcriptional regulator -
NLX84_RS19940 (NLX84_19940) 4193858..4194766 - 909 WP_085058844.1 LysR family transcriptional regulator -
NLX84_RS19945 (NLX84_19945) 4194875..4195759 + 885 WP_004931820.1 MBL fold metallo-hydrolase -
NLX84_RS19950 (NLX84_19950) 4195834..4196481 + 648 WP_033632219.1 DsbA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-85)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13330.40 Da        Isoelectric Point: 10.0507

>T251402 WP_048324788.1 NZ_CP100765:4190831-4191175 [Serratia nematodiphila]
MWQVVTVERFDDWFLALNNAQQTSILAAIYKLQTFGPQLARPHADTLHFSDAVRQLKELRIQHRGCPFRVFFAFDPQRQA
VLLCGGDKTGDKRFYQRMLPIAAMEFSHYLATRR

Download         Length: 345 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11080.97 Da        Isoelectric Point: 10.1998

>AT251402 WP_004931828.1 NZ_CP100765:4191181-4191483 [Serratia nematodiphila]
MAKPLSQLIDKLDPAVVAAARQKADQEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A086GAN0

References