Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 423269..423771 Replicon chromosome
Accession NC_015224
Organism Yersinia enterocolitica subsp. palearctica 105.5R(r)

Toxin (Protein)


Gene name yoeB Uniprot ID A0A7T9Y4I7
Locus tag YE105_RS01910 Protein ID WP_005156563.1
Coordinates 423517..423771 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A7U7FIK7
Locus tag YE105_RS01905 Protein ID WP_005156566.1
Coordinates 423269..423520 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YE105_RS01895 418622..420367 + 1746 WP_013649105.1 ABC transporter ATP-binding protein/permease -
YE105_RS01900 420352..423138 + 2787 WP_013649106.1 insulinase family protein -
YE105_RS01905 423269..423520 + 252 WP_005156566.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
YE105_RS01910 423517..423771 + 255 WP_005156563.1 Txe/YoeB family addiction module toxin Toxin
YE105_RS01915 423795..426131 - 2337 WP_005156561.1 mechanosensitive ion channel family protein -
YE105_RS01920 426550..428682 + 2133 WP_013649108.1 TonB-dependent siderophore receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10097.60 Da        Isoelectric Point: 9.4486

>T25139 WP_005156563.1 NC_015224:423517-423771 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
VRIIFSSCSWEDYLYWQQTDKKILKRINELVKNIQRTPFEGKGKPEPLKHNLAGFWSRRITEEHRLVYEVSGDNLLIAAC
RYHY

Download         Length: 255 bp

>T25139 NC_015224:423517-423771 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
GTGAGAATTATATTTTCCAGTTGTTCTTGGGAGGATTATCTTTATTGGCAACAAACGGATAAGAAAATCCTCAAACGCAT
TAATGAGTTAGTAAAAAATATTCAAAGAACGCCATTTGAGGGAAAGGGTAAACCGGAACCCCTTAAACATAATCTGGCAG
GGTTCTGGTCACGGAGGATTACAGAAGAGCACAGACTTGTTTATGAGGTTTCCGGTGATAATTTATTAATTGCTGCTTGT
CGTTACCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9447.66 Da        Isoelectric Point: 4.4878

>AT25139 WP_005156566.1 NC_015224:423269-423520 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
MRTISYSEARQNLSTTMVQTVEDRAPILITRQNGTSCVLMSLEEYESLEETAYLLRSPANAKHLMDSIEELRAGKGIQRE
LEE

Download         Length: 252 bp

>AT25139 NC_015224:423269-423520 [Yersinia enterocolitica subsp. palearctica 105.5R(r)]
ATGAGAACAATTAGTTATAGTGAGGCGCGCCAGAATTTGTCGACAACGATGGTGCAAACGGTTGAGGATCGAGCCCCCAT
CCTCATCACTCGTCAAAATGGGACTTCTTGTGTTCTTATGTCACTTGAAGAATATGAATCATTGGAAGAAACTGCTTATT
TACTGCGCTCACCAGCAAACGCGAAGCATTTGATGGACTCAATTGAAGAGTTGAGAGCAGGAAAAGGAATTCAAAGGGAA
CTTGAAGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T9Y4I7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7FIK7

References