Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 581223..581876 Replicon chromosome
Accession NZ_CP100764
Organism Serratia plymuthica strain SASK2000

Toxin (Protein)


Gene name higB Uniprot ID A0A7U3YYL4
Locus tag NLX81_RS02730 Protein ID WP_013811355.1
Coordinates 581223..581573 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NLX81_RS02735 Protein ID WP_013811356.1
Coordinates 581577..581876 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLX81_RS02705 (NLX81_02705) 576702..577793 + 1092 WP_004949798.1 dimethyl sulfone monooxygenase SfnG -
NLX81_RS02710 (NLX81_02710) 577795..578496 - 702 WP_006323392.1 trehalose-6-phosphate synthase -
NLX81_RS02715 (NLX81_02715) 578511..579050 - 540 WP_013811352.1 GNAT family N-acetyltransferase -
NLX81_RS02720 (NLX81_02720) 579108..580487 - 1380 WP_013811353.1 glutamine synthetase family protein -
NLX81_RS02725 (NLX81_02725) 580743..581057 + 315 WP_013811354.1 hypothetical protein -
NLX81_RS02730 (NLX81_02730) 581223..581573 + 351 WP_013811355.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NLX81_RS02735 (NLX81_02735) 581577..581876 + 300 WP_013811356.1 helix-turn-helix transcriptional regulator Antitoxin
NLX81_RS02740 (NLX81_02740) 581969..583045 - 1077 WP_013811357.1 YncE family protein -
NLX81_RS02745 (NLX81_02745) 583331..584554 - 1224 WP_239440976.1 Bcr/CflA family efflux MFS transporter -
NLX81_RS02750 (NLX81_02750) 584599..585822 - 1224 WP_013811359.1 cytochrome P450 -
NLX81_RS02755 (NLX81_02755) 585837..586094 - 258 WP_013811360.1 acyl carrier protein -
NLX81_RS02760 (NLX81_02760) 586141..586692 - 552 WP_254754845.1 NADPH-dependent FMN reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13456.56 Da        Isoelectric Point: 8.5393

>T251377 WP_013811355.1 NZ_CP100764:581223-581573 [Serratia plymuthica]
MWTVITTEEFDRWFAVQDELTQEKVLAALVLLERSGPNLSRPFVDSLRGSQHPNMKELRVQHKGRPIRAFFAFDSLRQAI
VLCAGDKTGNEKRFYKVMLPIADAQFTQHLMCNFKE

Download         Length: 351 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11183.85 Da        Isoelectric Point: 5.1667

>AT251377 WP_013811356.1 NZ_CP100764:581577-581876 [Serratia plymuthica]
MGTLKDMLASRTPESLQRIEEMAQEMWLEARLYQLREALNISQQELANNLGISQPSVAAIEQRGNELKISTLKRYVEAMG
GTLRLDVELPDGKHVGFRV

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U3YYL4

Antitoxin

Source ID Structure

References