251371

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1494593..1495210 Replicon chromosome
Accession NZ_CP100755
Organism Alcaligenes sp. NLF5-7

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MID00_RS07025 Protein ID WP_250756474.1
Coordinates 1494593..1494889 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MID00_RS07030 Protein ID WP_254500079.1
Coordinates 1494899..1495210 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MID00_RS07010 (MID00_07010) 1490380..1491273 - 894 WP_254500078.1 MurR/RpiR family transcriptional regulator -
MID00_RS07015 (MID00_07015) 1491438..1491716 - 279 WP_009460160.1 acylphosphatase -
MID00_RS07020 (MID00_07020) 1491909..1494458 + 2550 WP_250756475.1 EAL domain-containing protein -
MID00_RS07025 (MID00_07025) 1494593..1494889 + 297 WP_250756474.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MID00_RS07030 (MID00_07030) 1494899..1495210 + 312 WP_254500079.1 HigA family addiction module antitoxin Antitoxin
MID00_RS07035 (MID00_07035) 1495279..1496646 - 1368 WP_251196990.1 DNA recombination protein RmuC -
MID00_RS07040 (MID00_07040) 1496925..1497935 + 1011 WP_254500080.1 acyltransferase family protein -
MID00_RS07045 (MID00_07045) 1498128..1499375 - 1248 WP_254500081.1 D-amino acid dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-98)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11092.48 Da        Isoelectric Point: 9.3459

>T251371 WP_250756474.1 NZ_CP100755:1494593-1494889 [Alcaligenes sp. NLF5-7]
MIKSFRHKGLQAYFETGSKSGIQAKHAVRLQIQLTALHAATQAEDMNAPGWKLHKLSGKNPKGQSVQDHYTISVSGNWRL
TFYFEGEDAVLVDYQDYH

Download         Length: 297 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11517.15 Da        Isoelectric Point: 9.8524

>AT251371 WP_254500079.1 NZ_CP100755:1494899-1495210 [Alcaligenes sp. NLF5-7]
MRMHNPSHPGPVLREYLGELSVTEAASRLGVTRAALSRILNGSAGISADMALRLRDALGTSAEMWINMQSHYDLWQAEQK
PRPKVLSFHGPRPCLSHDEQNRK

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References