Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1324836..1325496 Replicon chromosome
Accession NZ_CP100753
Organism Serratia marcescens strain SASK1000

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NLX77_RS06230 Protein ID WP_118891868.1
Coordinates 1324836..1325189 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A6G8TPX9
Locus tag NLX77_RS06235 Protein ID WP_004935502.1
Coordinates 1325194..1325496 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLX77_RS06210 (NLX77_06210) 1320939..1321304 + 366 WP_004935528.1 diacylglycerol kinase -
NLX77_RS06215 (NLX77_06215) 1321397..1322296 + 900 WP_075686404.1 LysR family transcriptional regulator -
NLX77_RS06220 (NLX77_06220) 1322271..1323077 - 807 WP_118891867.1 substrate-binding domain-containing protein -
NLX77_RS06225 (NLX77_06225) 1323104..1324399 - 1296 WP_004935508.1 MFS transporter -
NLX77_RS06230 (NLX77_06230) 1324836..1325189 + 354 WP_118891868.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NLX77_RS06235 (NLX77_06235) 1325194..1325496 + 303 WP_004935502.1 XRE family transcriptional regulator Antitoxin
NLX77_RS06240 (NLX77_06240) 1325619..1326527 - 909 WP_254520193.1 LysR family transcriptional regulator -
NLX77_RS06245 (NLX77_06245) 1326666..1327586 + 921 WP_031300707.1 alpha/beta hydrolase -
NLX77_RS06250 (NLX77_06250) 1327586..1328522 + 937 Protein_1218 alpha/beta hydrolase -
NLX77_RS06255 (NLX77_06255) 1328538..1329173 + 636 WP_015378474.1 SDR family oxidoreductase -
NLX77_RS06260 (NLX77_06260) 1329216..1329944 + 729 WP_226882923.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1315913..1332701 16788


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-79)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13575.59 Da        Isoelectric Point: 9.0493

>T251359 WP_118891868.1 NZ_CP100753:1324836-1325189 [Serratia marcescens]
VWEIKTTDAFDHWLRSLSDADRACVLAALMVLREKGPGLPRPYADTVKGSRYSNMKELRIQSRGEPLRAFFAFDPYRIGM
VLCAGNKAGDEKRFYDRMLQIADREFTNWLNTLKEKE

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11142.96 Da        Isoelectric Point: 5.1992

>AT251359 WP_004935502.1 NZ_CP100753:1325194-1325496 [Serratia marcescens]
MGRTLEQLIAEEKPEVVAEAQAMATDIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G8TPX9

References