Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 574023..574675 Replicon chromosome
Accession NZ_CP100753
Organism Serratia marcescens strain SASK1000

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NLX77_RS02745 Protein ID WP_004931830.1
Coordinates 574331..574675 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A086GAN0
Locus tag NLX77_RS02740 Protein ID WP_004931828.1
Coordinates 574023..574325 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLX77_RS02715 (NLX77_02715) 569030..569677 - 648 WP_015378930.1 DsbA family protein -
NLX77_RS02720 (NLX77_02720) 569746..570630 - 885 WP_254520113.1 MBL fold metallo-hydrolase -
NLX77_RS02725 (NLX77_02725) 570739..571647 + 909 WP_015378928.1 LysR family transcriptional regulator -
NLX77_RS02730 (NLX77_02730) 571675..572598 - 924 WP_254520114.1 LysR family transcriptional regulator -
NLX77_RS02735 (NLX77_02735) 572733..573995 + 1263 WP_004931826.1 diaminopimelate decarboxylase -
NLX77_RS02740 (NLX77_02740) 574023..574325 - 303 WP_004931828.1 XRE family transcriptional regulator Antitoxin
NLX77_RS02745 (NLX77_02745) 574331..574675 - 345 WP_004931830.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NLX77_RS02750 (NLX77_02750) 574835..575854 - 1020 WP_004931832.1 HTH-type transcriptional regulator GalR -
NLX77_RS02755 (NLX77_02755) 576076..578334 + 2259 WP_118891741.1 molybdopterin guanine dinucleotide-containing S/N-oxide reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-85)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13383.44 Da        Isoelectric Point: 10.6087

>T251357 WP_004931830.1 NZ_CP100753:c574675-574331 [Serratia marcescens]
MWQVVTVERFDDWFLALNNAQQTSILAAIYKLQTFGPQLARPHADTLHFSDAVRQLKELRIQHRGRPFRVFFAFDPQRQA
VLLCGGDKTGDKRFYQRMLPIAAMEFSHYLATRR

Download         Length: 345 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11080.97 Da        Isoelectric Point: 10.1998

>AT251357 WP_004931828.1 NZ_CP100753:c574325-574023 [Serratia marcescens]
MAKPLSQLIDKLDPAVVAAARQKADQEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A086GAN0

References