Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 157373..158103 Replicon chromosome
Accession NZ_CP100753
Organism Serratia marcescens strain SASK1000

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NLX77_RS00715 Protein ID WP_118891648.1
Coordinates 157792..158103 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NLX77_RS00710 Protein ID WP_015379178.1
Coordinates 157373..157795 (-) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLX77_RS00695 (NLX77_00695) 153232..153972 + 741 WP_004937022.1 KDGP aldolase family protein -
NLX77_RS00700 (NLX77_00700) 154187..155401 + 1215 WP_015379180.1 lactonase family protein -
NLX77_RS00705 (NLX77_00705) 155453..157369 + 1917 WP_254520073.1 PRD domain-containing protein -
NLX77_RS00710 (NLX77_00710) 157373..157795 - 423 WP_015379178.1 helix-turn-helix domain-containing protein Antitoxin
NLX77_RS00715 (NLX77_00715) 157792..158103 - 312 WP_118891648.1 type II toxin-antitoxin system HigB family toxin Toxin
NLX77_RS00720 (NLX77_00720) 158401..158670 - 270 Protein_136 PTS phosphocarrier protein NPr -
NLX77_RS00725 (NLX77_00725) 158667..159521 - 855 WP_015379177.1 RNase adapter RapZ -
NLX77_RS00730 (NLX77_00730) 159649..160110 - 462 WP_016930212.1 PTS IIA-like nitrogen regulatory protein PtsN -
NLX77_RS00735 (NLX77_00735) 160266..160553 - 288 WP_004937038.1 ribosome hibernation promoting factor -
NLX77_RS00740 (NLX77_00740) 160577..162010 - 1434 WP_021505109.1 RNA polymerase factor sigma-54 -
NLX77_RS00745 (NLX77_00745) 162063..162788 - 726 WP_254520074.1 LPS export ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(81-135)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12319.16 Da        Isoelectric Point: 10.0957

>T251354 WP_118891648.1 NZ_CP100753:c158103-157792 [Serratia marcescens]
MHIISREPFNNATKQYPNEATALEAIYKTLRRGEFRTPDELKALFPSLDRMKYKEKWWVIDVGGNHLRILFFASFETQKV
FIKHIVSHAEYDKLMQHYRRSSS

Download         Length: 312 bp

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15784.13 Da        Isoelectric Point: 5.2139

>AT251354 WP_015379178.1 NZ_CP100753:c157795-157373 [Serratia marcescens]
MITDAIKAADALLRAVPLLQGSRAQQDYREALELVEYLLENDEHHPLIDMLAKKIAEYEDNSAEFTAFNQRIAQLPQGVA
ALRVLMEQHQLSQSDFEHEIGKKSLVNQILNGKRSLTIPHIMALAKRFNLPPALFLPEAD

Download         Length: 423 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References