Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 4459522..4460276 | Replicon | chromosome |
| Accession | NZ_CP100747 | ||
| Organism | Salmonella enterica subsp. enterica serovar Montevideo strain R17.4849 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | B5F003 |
| Locus tag | NL707_RS21680 | Protein ID | WP_000558166.1 |
| Coordinates | 4459522..4459833 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | NL707_RS21685 | Protein ID | WP_001259009.1 |
| Coordinates | 4459830..4460276 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NL707_RS21650 (4455180) | 4455180..4456082 | + | 903 | WP_000331361.1 | formate dehydrogenase subunit beta | - |
| NL707_RS21655 (4456079) | 4456079..4456714 | + | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
| NL707_RS21660 (4456711) | 4456711..4457640 | + | 930 | WP_000027730.1 | formate dehydrogenase accessory protein FdhE | - |
| NL707_RS21665 (4457687) | 4457687..4457977 | - | 291 | WP_000362052.1 | DNA-binding transcriptional regulator | - |
| NL707_RS21670 (4457978) | 4457978..4458289 | - | 312 | WP_001159630.1 | cytotoxic translational repressor of toxin-antitoxin stability system | - |
| NL707_RS21675 (4458507) | 4458507..4459436 | + | 930 | WP_001127694.1 | alpha/beta hydrolase | - |
| NL707_RS21680 (4459522) | 4459522..4459833 | + | 312 | WP_000558166.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| NL707_RS21685 (4459830) | 4459830..4460276 | + | 447 | WP_001259009.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
| NL707_RS21690 (4460291) | 4460291..4461232 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| NL707_RS21695 (4461277) | 4461277..4461714 | - | 438 | WP_000560969.1 | D-aminoacyl-tRNA deacylase | - |
| NL707_RS21700 (4461711) | 4461711..4462583 | - | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
| NL707_RS21705 (4462577) | 4462577..4463176 | - | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
| NL707_RS21710 (4463367) | 4463367..4464170 | - | 804 | WP_000059693.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| NL707_RS21715 (4464204) | 4464204..4465100 | - | 897 | WP_001528888.1 | sugar kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12432.40 Da Isoelectric Point: 9.5334
>T251351 WP_000558166.1 NZ_CP100747:4459522-4459833 [Salmonella enterica subsp. enterica serovar Montevideo]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
Download Length: 312 bp
Antitoxin
Download Length: 149 a.a. Molecular weight: 16720.06 Da Isoelectric Point: 6.6451
>AT251351 WP_001259009.1 NZ_CP100747:4459830-4460276 [Salmonella enterica subsp. enterica serovar Montevideo]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|