Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4542087..4542689 Replicon chromosome
Accession NZ_CP100744
Organism Salmonella enterica subsp. enterica serovar Newport strain R18.0234

Toxin (Protein)


Gene name higB Uniprot ID V7IUJ1
Locus tag FGU68_RS21940 Protein ID WP_001159632.1
Coordinates 4542378..4542689 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FGU68_RS21935 Protein ID WP_000362050.1
Coordinates 4542087..4542377 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGU68_RS21920 (4539580) 4539580..4540482 + 903 WP_000331365.1 formate dehydrogenase subunit beta -
FGU68_RS21925 (4540479) 4540479..4541114 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
FGU68_RS21930 (4541111) 4541111..4542040 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
FGU68_RS21935 (4542087) 4542087..4542377 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
FGU68_RS21940 (4542378) 4542378..4542689 - 312 WP_001159632.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
FGU68_RS21945 (4542907) 4542907..4543836 + 930 WP_001127702.1 alpha/beta hydrolase -
FGU68_RS21950 (4543922) 4543922..4544233 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
FGU68_RS21955 (4544230) 4544230..4544676 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
FGU68_RS21960 (4544691) 4544691..4545632 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
FGU68_RS21965 (4545677) 4545677..4546114 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
FGU68_RS21970 (4546111) 4546111..4546983 - 873 WP_000921423.1 virulence factor BrkB family protein -
FGU68_RS21975 (4546977) 4546977..4547576 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12342.27 Da        Isoelectric Point: 9.4460

>T251335 WP_001159632.1 NZ_CP100744:c4542689-4542378 [Salmonella enterica subsp. enterica serovar Newport]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT251335 WP_000362050.1 NZ_CP100744:c4542377-4542087 [Salmonella enterica subsp. enterica serovar Newport]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4U7VQ31

Antitoxin

Source ID Structure

References