Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4604034..4604636 Replicon chromosome
Accession NZ_CP100736
Organism Salmonella enterica subsp. enterica serovar Agona strain R18.1477

Toxin (Protein)


Gene name higB Uniprot ID V7IUJ1
Locus tag NL742_RS22205 Protein ID WP_001159632.1
Coordinates 4604325..4604636 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NL742_RS22200 Protein ID WP_000362051.1
Coordinates 4604034..4604324 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL742_RS22185 (4601527) 4601527..4602429 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
NL742_RS22190 (4602426) 4602426..4603061 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
NL742_RS22195 (4603058) 4603058..4603987 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
NL742_RS22200 (4604034) 4604034..4604324 - 291 WP_000362051.1 NadS family protein Antitoxin
NL742_RS22205 (4604325) 4604325..4604636 - 312 WP_001159632.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
NL742_RS22210 (4604854) 4604854..4605783 + 930 WP_001127697.1 alpha/beta hydrolase -
NL742_RS22215 (4605869) 4605869..4606180 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
NL742_RS22220 (4606177) 4606177..4606623 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
NL742_RS22225 (4606638) 4606638..4607579 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
NL742_RS22230 (4607624) 4607624..4608061 - 438 WP_000560973.1 D-aminoacyl-tRNA deacylase -
NL742_RS22235 (4608058) 4608058..4608930 - 873 WP_000921423.1 virulence factor BrkB family protein -
NL742_RS22240 (4608924) 4608924..4609523 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12342.27 Da        Isoelectric Point: 9.4460

>T251297 WP_001159632.1 NZ_CP100736:c4604636-4604325 [Salmonella enterica subsp. enterica serovar Agona]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10957.57 Da        Isoelectric Point: 10.6525

>AT251297 WP_000362051.1 NZ_CP100736:c4604324-4604034 [Salmonella enterica subsp. enterica serovar Agona]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKVKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4U7VQ31

Antitoxin

Source ID Structure

References