Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4593046..4593648 Replicon chromosome
Accession NZ_CP100732
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain R18.1932

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag NL737_RS22225 Protein ID WP_001159630.1
Coordinates 4593337..4593648 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NL737_RS22220 Protein ID WP_000362050.1
Coordinates 4593046..4593336 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL737_RS22205 (4590539) 4590539..4591441 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
NL737_RS22210 (4591438) 4591438..4592073 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
NL737_RS22215 (4592070) 4592070..4592999 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
NL737_RS22220 (4593046) 4593046..4593336 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
NL737_RS22225 (4593337) 4593337..4593648 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
NL737_RS22230 (4593866) 4593866..4594795 + 930 WP_001127703.1 alpha/beta hydrolase -
NL737_RS22235 (4594881) 4594881..4595192 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
NL737_RS22240 (4595189) 4595189..4595635 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
NL737_RS22245 (4595650) 4595650..4596591 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
NL737_RS22250 (4596636) 4596636..4597073 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
NL737_RS22255 (4597070) 4597070..4597942 - 873 WP_000921427.1 virulence factor BrkB family protein -
NL737_RS22260 (4597936) 4597936..4598535 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T251274 WP_001159630.1 NZ_CP100732:c4593648-4593337 [Salmonella enterica subsp. enterica serovar Typhimurium]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT251274 WP_000362050.1 NZ_CP100732:c4593336-4593046 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References