Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HipB
Location 2685360..2686038 Replicon chromosome
Accession NC_015172
Organism Syntrophobotulus glycolicus DSM 8271

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag SGLY_RS13375 Protein ID WP_013625760.1
Coordinates 2685679..2686038 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag SGLY_RS13370 Protein ID WP_013625759.1
Coordinates 2685360..2685677 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SGLY_RS13330 2680726..2681574 - 849 WP_013625752.1 ABC-2 family transporter protein -
SGLY_RS13335 2681564..2682331 - 768 WP_013625753.1 hypothetical protein -
SGLY_RS13340 2682426..2682629 - 204 WP_013625754.1 hypothetical protein -
SGLY_RS13345 2682741..2683027 - 287 Protein_2597 helix-turn-helix transcriptional regulator -
SGLY_RS17640 2683024..2683348 - 325 Protein_2598 type II toxin-antitoxin system RelE/ParE family toxin -
SGLY_RS13355 2683415..2683840 - 426 WP_013625756.1 type II toxin-antitoxin system HicB family antitoxin -
SGLY_RS13360 2683876..2684063 - 188 Protein_2600 type II toxin-antitoxin system HicA family toxin -
SGLY_RS13365 2684241..2685137 + 897 WP_013625758.1 site-specific integrase -
SGLY_RS13370 2685360..2685677 - 318 WP_013625759.1 helix-turn-helix domain-containing protein Antitoxin
SGLY_RS13375 2685679..2686038 - 360 WP_013625760.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SGLY_RS13380 2686105..2686308 - 204 WP_013625761.1 helix-turn-helix transcriptional regulator -
SGLY_RS13385 2686714..2687091 + 378 WP_013625762.1 hypothetical protein -
SGLY_RS13390 2687088..2687681 + 594 WP_013625763.1 hypothetical protein -
SGLY_RS17205 2687668..2687919 + 252 WP_052298647.1 Arm DNA-binding domain-containing protein -
SGLY_RS17210 2688004..2688441 + 438 WP_052298648.1 hypothetical protein -
SGLY_RS13400 2688541..2690073 - 1533 WP_013625764.1 glutamine-hydrolyzing GMP synthase -
SGLY_RS13405 2690144..2690689 - 546 WP_013625765.1 hypoxanthine phosphoribosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL 2636446..2696890 60444


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(31-112)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-87)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 14394.57 Da        Isoelectric Point: 9.6456

>T25127 WP_013625760.1 NC_015172:c2686038-2685679 [Syntrophobotulus glycolicus DSM 8271]
MFIVIIYEDKSGKSPVTEYIDDLDLKALTSKDSRIRLKKIYQYFELLKMYGSRAGLPASKHIEDDIWELRPTNDRFFYAY
WKEDTFVILHHYIKKTQKAPRQEIEQAKRNLKDFLERSR

Download         Length: 360 bp

>T25127 NC_015172:c2686038-2685679 [Syntrophobotulus glycolicus DSM 8271]
ATGTTCATCGTAATAATTTACGAGGACAAAAGCGGCAAATCGCCGGTTACTGAATATATTGATGATTTGGATTTGAAGGC
CCTAACGAGCAAAGACAGTCGTATTCGGCTCAAAAAAATATACCAATATTTTGAGTTGCTGAAAATGTATGGTTCTCGGG
CTGGTCTGCCGGCATCAAAGCACATTGAAGATGATATTTGGGAGCTGCGGCCTACCAATGATCGGTTTTTTTATGCATAC
TGGAAAGAGGATACATTTGTTATCCTTCACCATTACATAAAGAAAACCCAAAAAGCGCCGCGGCAAGAGATTGAGCAAGC
AAAACGAAATCTGAAAGATTTTTTGGAAAGGAGCAGGTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11469.11 Da        Isoelectric Point: 5.1407

>AT25127 WP_013625759.1 NC_015172:c2685677-2685360 [Syntrophobotulus glycolicus DSM 8271]
MAIGRNWDDVKNGLTSLSQDEKDEIDFQVKLVGEILSARKEKGMTQAELDALCGINQTHIARIENNKADPQLSTIFKILR
PLGKTLAVVDVPPAVSTPTGAQEVR

Download         Length: 318 bp

>AT25127 NC_015172:c2685677-2685360 [Syntrophobotulus glycolicus DSM 8271]
ATGGCTATCGGTAGAAATTGGGATGATGTAAAAAACGGTTTGACCTCCTTGTCGCAAGATGAAAAGGATGAAATTGACTT
CCAAGTGAAGCTTGTGGGTGAGATTCTGTCTGCCCGAAAAGAAAAGGGAATGACCCAAGCCGAGCTTGATGCACTCTGTG
GAATCAATCAGACTCATATCGCGCGGATTGAAAATAACAAAGCGGATCCGCAGCTTTCAACTATTTTCAAAATTCTGCGT
CCACTTGGGAAAACTCTGGCAGTGGTAGATGTTCCTCCAGCAGTATCAACTCCCACCGGAGCACAAGAAGTAAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References